期刊文献+

急性脑梗死患者同型半胱氨酸、EGF、VEGF检测的临床意义 被引量:1

The clinical significance of Hcy, EGF and VEGF detection in patients with acute cerebral infarction
在线阅读 下载PDF
导出
摘要 目的:探讨急性脑梗死患者血Hcy、EGF、VEGF浓度与疾病严重程度的关系。方法:选择109例急性脑梗死患者为研究对象,同期住院最近无新发脑梗死患者30例为对照组。入院时进行神经功能缺损评分并经CT或MRt测量脑梗死体积,分为大、中、小梗死三组,同时测定被检者血Hcy、EGF、VEGF浓度。结果:急性脑梗死患者血Hcy、VEGF水平明显高于对照组(P〈0.01),EGF水平明显低于对照组(P〈0.01),大、中、小梗死三组血Hcy、EGF、VEGF浓度两两比较均有差异。结论:Hcy、EGF、vEGF联合检测在判断急性脑梗死的损伤程度和预后有较重要的指导价值。 Objective : To explore the relationship between disease severity and Hcy, EGF, VEGF concentrations of patients with acute cerebral infarction. Methods : A total of 30 healthy persons and 109 acute cerebral infarction patients' serum Hcy, EGF and VEGF were detected. Patients with acute cerebral infarction were divided into large, medium and small groups by CT or MRI measurements, and nerve function defect grade on admission.Results : As for acute cerebral infarction, serum Hcy and VEGF were significantly higher than control groups ( P〈0.01 ) ,but serum EGF was significantly lower than control groups ( P〈0.01 ) .There were significant difference between large, medium and small groups . Conclusions : Hey, EGF and VEGF joint detection plays an important role in judging the damage degree and prognosis of acute cerebral infarction.
出处 《医学检验与临床》 2014年第6期61-62,93,共3页 Medical Laboratory Science and Clinics
关键词 急性脑梗死 HCY EGF VEGF Cerebral infarction Hcy EGF VEGF
  • 相关文献

参考文献14

二级参考文献106

共引文献258

同被引文献19

  • 1Ferrara N,Henzel WJ,Pituitaty follicular cells secrete a heparinbinding growth factor specifie for vascular endothelial cells[J].Biochem Biophys Res Commun,1989,161(2):851-858.
  • 2Donald RS,Livingston VD,Lawrence FB,et al.Vaseular permeability factor in tumorbiology[J].Cancer Metastassis Rev,1993,12(2):303-307.
  • 3Koyama J.Miyake S,Sasayama T,et al.The novel VEGF receptor antagonist,VGAI 155,reduces edema,decreases infarct and improves neurological function after stroke in rats[J].Kobe J Med Sci,2010,56(1):1-11.
  • 4Gutierez-Fernandez M.Rodriguez-Frutos B.AlvarezGrech J.Functional recovery after hematic adminstration of allogenic mesenchymal stem cells in acute ischemic stroke in rats[J].Neuros cience,2011,175(4):394-405.
  • 5Patruno R.Arpaia N,Gadaleta CD,et al.VEGF concentration from plasmactivated platelets rich correlates with microvascular density and grading in canine mast cell tumour spontaneous model[J].J Cell Mol Med,2009,13(3):555-561.
  • 6Sun Y,Jin K,Lin X,et al.VEGF-induced neuroprotection,neurogenesis,and angiogenesis after focal cerebral ischemia[J].J Clin Invest,2003,111(12):1843-1847.
  • 7史福平,邸卫英,王惠凌,等.血清VEGF和TNF-α在急性脑梗死患者中的动态变化研究[J].中国急救医学,2013,33(8)增刊:4-6.
  • 8Peng Hu Y,Feng N.L-3-n-butyl-phthalide allevares hydrogen peroxide-induced apoptosis by PKG pathway in human nearoblastoma SK-N-SH cells[J].Nattnyn Schniedebergs Arch Pharnael,2011,383(1):91-99.
  • 9Li J,Li Y,Ogle M,et al.DL-3-n-butylphthalide prevents neuronal cell death after focal cerebral ischemia in mice via the JNK pathway[J].Brain Res,2010,1359(2):216-226.
  • 10俞鸣.急性脑梗死患者血清血管内皮生长因子和基质金属蛋白酶-9水平的动态变化及其意义[J].中国全科医学,2010,13(18):1983-1985. 被引量:10

引证文献1

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部