摘要
为探讨山药多糖的抗应激作用及其机制。将120只雄性SPF级昆明种小鼠随机分为4组,即对照组和山药多糖低、中、高剂量组,每只小鼠每天分别以0、100、200、400 mg/kg的剂量饲喂山药多糖,试验期30 d,测定小鼠力竭游泳时间及运动后肝糖原、血清尿素氮、血乳酸含量。结果显示,与对照组相比,山药多糖各剂量组小鼠力竭游泳时间和运动后肝糖原含量均提高,低剂量组与对照组差异不显著,中、高剂量组均极显著提高,力竭游泳时间分别提高99.03%、199.64%,运动后肝糖原含量分别提高73.44%、154.39%;运动后山药多糖各剂量组小鼠体内血清尿素氮、血乳酸含量均降低,低剂量组与对照组差异不显著,中、高剂量组均极显著降低,血清尿素氮含量分别降低28.44%、43.75%,血乳酸含量分别降低15.22%、24.29%。可见,山药多糖具有显著的抗应激作用,且有明显的量效关系。
The aim of the study was to investigate the mechanism of the anti-stress effect of Chinese yam polysaccharides（YP） in mice.A total of 120 male Kunming mice of SPF grade were randomly divided into 4 groups：normal control（0 mg /（kg·d））,low dosages group（100 mg /（kg·d））,middle dosages group（200 mg /（kg·d）） and high dosages group of YP（400 mg /（kg·d））.At the end of the 30 day＇s administration,exhaustive swimming time,liver glycogen,serum urea nitrogen and blood lactic acid content were determined to evaluated the anti-stress effect.Compared with the control,the exhaustive swimming time of middle dosages and high dosages groups significantly increased by 99.03% and 199.64%,respectively.The liver glycogen content of middle dosages and high dosages groups significantly increased by 73.44% and 154.39%,respectively.The serum urea nitrogen content of middle dosages and high dosages groups significantly decreased by 28.44% and 43.75%,respectively.The blood lactic acid content of middle dosages and high dosages groups significantly decreased by 15.22% and 24.29%,respectively.The low dosages group showed no significant difference compared with the control.The results of the study indicated that YP was able to significantly alleviate the stress with a dose-dependent manner in mice.
出处
《河南农业科学》
CSCD
北大核心
2015年第1期143-145,共3页
Journal of Henan Agricultural Sciences
关键词
山药多糖
小鼠
抗应激
尿素氮
肝糖原
血乳酸
Chinese yam polysaccharides
mice
anti-stress
serum urea nitrogen
liver glycogen
blood lactic acid
