摘要
目的:研究腹腔镜与开手术对直肠癌患者术后Th1和Th2类细胞因子漂移的影响。方法:选取于本院普外科接受手术治疗的直肠癌患者纳入研究,根据手术方法不同分为两组,观察组接受腹腔镜下手术、对照组接受开腹手术。比较两组的应激反应程度、Th1/Th2细胞含量以及Th1/Th2细胞因子含量。结果:(1)应激反应:观察组的促肾上腺皮质激素(ACTH)、皮质醇(Cor)、去甲肾上腺素(NE)、肾上腺素(E)水平均低于对照组,差异有统计学意义(P<0.05);(2)Th1/Th2细胞含量:观察组的Th1细胞含量、Th1/Th2细胞比例均高于对照组,Th2细胞含量低于对照组,差异有统计学意义(P<0.05);(3)Th1/Th2细胞因子含量:观察组的白介素-2(IL-2)、干扰素-γ(IFN-γ)含量高于对照组,白介素-6(IL-6)、白介素-10(IL-10)含量低于对照组,差异有统计学意义(P<0.05)。结论:腹腔镜下手术有助于缓解应激反应、改善Th1/Th2细胞漂移,增强Th1细胞功能、而抑制Th2细胞功能,是治疗直肠癌更为理想的手术方法。
Objective： To study the effect of laparoscopic and open surgery on Th1 and Th2 cytokines in rectal cancer patients. Methods： Rectal cancer patients with surgery from 2012 April to 2014 April were enrolled and divided into two groups according to different surgical methods. In observation group patients received laparoscopic surgery, while in control group patients received laparotomy. Then stress reaction degree, Th1/Th2 cell content and Th1/Th2 cytokines content were compared. Results： ACTH, Cot, NE, E levels of observation group were lower than those of control group. Th1 cell content, Th1/Th2 cell ratio of observation group was higher than those of control group; Th2 cells content were lower than that of control group. IL-2, IFN-r contents of observation group were higher than those of control group; IL-6 and IL-10 contents were lower than those of control group. Conclusion： Laparoscopic surgery is helpful to relieve stress reaction, improve Th1/Th2 cell drift, enhance the function of Th1 cells and inhibit the function of Th2eell. It＇s an ideal method in treating rectal cancer.
出处
《海南医学院学报》
CAS
2014年第12期1669-1671,共3页
Journal of Hainan Medical University
基金
湖北省荆州市科技局基金(201283723)~~
