摘要
目的探讨抗N-甲基-M-天冬氨酸受体脑炎的发病率、病因及发病机制、临床表现、诊断、治疗及预后,以增加临床医生对该病的认识。方法对1例伴畸胎瘤的抗NMDA受体脑炎患者的临床资料进行总结。结果患者有典型的临床表现,血及脑脊液中抗NMDA受体抗体阳性,经手术切除肿瘤及免疫治疗后,预后良好。结论抗NMDA受体脑炎是一种自身免疫性疾病,漏诊误诊率高,血清和(或)脑脊液抗NMDA受体抗体阳性可诊断该病。早发现、早诊断、早治疗可缩短病程、改善预后。
Objective To investigate the incidence, etiology and pathogenesis, clinical manifestation, diagnosis, treatment and prognosis of anti-N-methyl-D-aspartate receptor （anti NMDAR） encephalitis to increase the clinicians＇ understanding of the disease. Methods The clinical data of 1 case that is anti NMDAR encephalitis occurs with ovarian teratomas was retrospectively summarized. Results The patient presented with typical clinical features of anti-NMDAR encephalitis and antibodies directed against NMDA receptors in serum or CSF can be detected, after surgical removal of the tumor and immunotheraphy, the prognosis is good. Conclusion Anti-N-methyl-D-aspartate receptor encephalitis is an autoimmune disorder; its missed diagnosis and misdiagnosis are high. Antibodies directed against NMDAR presented in the patient＇s serum and/or CSF can be diagnosed. Early detection, early diagnosis and early treatment can shorten the course and improve prognosis.
出处
《中国实用神经疾病杂志》
2014年第23期22-24,共3页
Chinese Journal of Practical Nervous Diseases
基金
国家自然科学基金(81301086
81100949)
