摘要
目的:评估阿托伐他汀与瑞舒伐他汀长期应用对冠心病患者血脂水平和肝功能的影响。方法:采用回顾性分析方法,选择我院住院冠心病患者200例,根据他汀类药物应用情况,分为阿托伐他汀组(102例)和瑞舒伐他汀组(98例),比较两组患者应用他汀后1周、1个月、3个月、6个月和12个月的血脂和肝功能水平变化。结果:两组患者治疗后各时期的TC、LDL-C水平差异均无统计学意义(P>0.05)。两组患者治疗后AST和ALT较治疗前显著升高(P<0.05),但两组间差异均无统计学意义(P>0.05)。结论:两种他汀降脂效果相似,但均可导致肝酶升高。
Objective： To evaluate the influence of atorvastatin and rosuvastatin on the lipid level and liver function in the patients with coronary heart disease（ CHD）. Methods： The CHD patients in our hospital were selected from January 2011 to December 2012.According to statin types,the patients were divided into atorvastatin group（ n = 102） and rosuvastatin group（ n = 98）,and the lipid level and liver function in the first week,and the first,third,6th and 12 th month after the statin treatment were evaluated. Results：TC and LDL-c levels of the two groups had no statistical differences in the same period（ P 0. 05）. AST and ALT levels were significantly increased after the statin treatment（ P 0. 05）,while no statistically significant difference was shown between the two groups（ P 0. 05）. Conclusion： Atorvastatin and rosuvastatin have the similar lipid-lowering effect,and both can increase liver enzymes.
出处
《中国药师》
CAS
2015年第2期255-257,共3页
China Pharmacist
关键词
瑞舒伐他汀
阿托伐他汀
冠心病
肝功能
肝损伤
Rosuvastatin
Atorvastatin
Coronary heart disease
Liver function
Liver damage
