摘要
目的探讨超敏C反应蛋白(hs-CRP)和脑钠肽(BNP)检测在慢性阻塞性肺疾病(COPD)并发肺心病中的临床意义。方法选取COPD急性加重合并肺心病患者80例设为观察组,另选取同期体检结果正常的健康人80例设为对照组。检测并比较2组血清hs-CRP水平和血浆BNP水平。结果观察组血清hs-CRP和血浆BNP水平均显著高于对照组(P<0.05);不同程度COPD合并肺心病患者的血清hs-CRP和血浆BNP水平的差异均有统计学意义(P<0.05);COPD合并肺心病患者疾病程度与患者的血清hs-CRP水平(rs=0.418)和血浆BNP水平(rs=0.519)均呈显著正相关(P<0.05)。结论血清hs-CRP和血浆BNP水平的上升提示COPD合并肺心病的发生风险,其上升幅度与患者的疾病严重程度具有相关性。
Objective To explore the clinical significance of high sensitivity C reactive pro- tein （hs-CRP） and brain natriuretic peptide （BNP） detections in the treatment of the patients with chronic obstructive pulmonary disease （COPD） complicated with pulmonary heart disease. Methods Eighty patients with acute exacerbation of COPD and chronic pulmonary heart disease were de- signed as observation group, and eighty healthy people with normal examination were designed as control group. The serum hs-CRP level and plasma BNP level were detected and compared between two groups. Results The serum hs-CRP and plasma BNP levels of the observation group were sig- nificantly higher than those of the control group （P 〈 0.05）. There were significant differences of serum hs-CRP and plasma BNP levels among pulmonary heart disease patients with different degrees of COPD （P 〈 0.05 ）. The levels of serum hs-CRP （ rs = 0. 418） and plasma BNP （ rs = 0. 519） were positively correlated with the degree of disease in patients with COPD complicated with pul- monary heart disease （P 〈 0.05）. Conclusion The raise of the serum hs-CRP and plasma BNP levels indicate the risk of COPD complicated with pulmonary heart disease, and the increasing ranges of the indicators above are correlated with the severity of the disease.
出处
《实用临床医药杂志》
CAS
2015年第1期29-31,48,共4页
Journal of Clinical Medicine in Practice
关键词
慢性阻塞性肺疾病
肺心病
超敏C反应蛋白
脑钠肽
chronic obstructive pulmonary disease
pulmonary heart disease
high sensitivity C reactive protein
brain natriuretic peptide
