摘要
目的探讨血脂异常对血清可溶性细胞间黏附分子-1(s ICAM-1)、血管细胞黏附分子-1(s VCAM-1)水平的影响,及血脂异常中医证候分型与血脂、血清黏附分子之间的关系。方法调查120例血脂异常患者中医证候类型,并检测血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、s ICAM-1、s VCAM-1水平,与正常健康人对照,并分析中医证候类型与检测指标相关性。结果 120例血脂异常患者中,肝肾阴虚证49例,阴虚阳亢证31例,痰浊阻遏证25例,脾肾阳虚证10例,气滞血瘀证5例。各型血脂异常患者血清s ICAM-1、s VCAM-1水平均较对照组显著上升(P<0.05)。在各组比较中发现,气滞血瘀组TC水平最高,且与肝肾阴虚组及阴虚阳亢组有显著差异(P<0.05)。痰浊阻遏组血清TG水平最高,且与阴虚阳亢组有显著差异(P<0.05)。结论肝肾阴虚证、阴虚阳亢证及痰浊阻遏证是血脂异常患者重要证候类型。TC升高可作为气滞血瘀证的诊断依据;血脂异常可使血清s ICAM-1及s VCAM-1水平升高。
Objective To explore the influence of dyslipidemia on serum soluble intercellular adhesion molecule-1 （sICAM-1） and soluble vascular cell adhesion molecule-1 （sVCAM-1）, and the relationship between TCM syndromes and serum lipemia, cell adhesion molecules. Methods TCM syndromes of 120 patients with dyslipidemia were determined, and whose serum TC ,TG, HDL-C, sICAM-land sVCAM-1 were test, compared with those of 20 healthy persons （normal group）. Results The distribution of TCM syndromes of patients was as the following： liver-kidney yin deficiency （ n = 49 ） , yin deficiency with yang hyperactivity （n = 31 ）, phlegm turbidity obstruction（ n = 25 ）, spleen-kidney yang deficiency （n = 10）, qi stagnation and blood stasis （ n = 5 ）. Furthermore, serum cell adhesion molecules in patients was significantly higher than normal group （P 〈 0.05 ）. Compared with liver-kidney yin deficiency group and yin deficiency with yang hyperactivity grouop, TC increased significantly in qi stagnation and blood stasis group; while TG in qi stagnation and blood stasis group increased compared with phlegm turbidity obstruction group （P 〈 0.05 ）. Conclusion The syndrome of liver-kidney yin deficiency, yin deficiency with yang hyperactivity and phlegm turbidity obstruction are main TCM syndromes. TC level can be used to be one of diagnose references in pattern of qi stagnation and blood stasis. And the levels of slCAM-1 and sVCAM-1 increase in patients with dyslipidemia.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2015年第1期53-56,共4页
Journal of Beijing University of Traditional Chinese Medicine
基金
高等学校博士学科点专项科研基金资助项目(No.20110013110002)
关键词
血脂异常
血清黏附分子
中医证型
dyslipidemia
serum cell adhesion molecules
TCM syndromes
