摘要
间充质干细胞或前体脂肪细胞向成熟脂肪细胞分化的复杂过程对哺乳动物脂肪组织的形成和脂肪代谢至关重要。脂肪形成受激素和各种生脂转录因子的调控,这些生脂转录因子以级联转录的方式表达,促进脂肪细胞分化,最终导致成熟脂肪细胞表型的形成。micro RNAs(mi RNAs)属于small RNA家族,分子长度约为22个核苷酸。近几年研究表明,mi RNA参与了许多生物过程的调控,包括细胞分化、转录因子和/或其他基因的转录后调控。该文对mi RNAs在小鼠、人类和家畜体外模型中作为促生脂或抗生脂因子来调节脂肪生成的研究成果进行总结,以期为研究mi RNA调控哺乳脂肪生成的相关科研人员提供参考。
The differentiation of adipocyte-derived from mesenchymal stem cells or preadlpocytes into mature adipocytes is essential for fat formation and metabolism of adipose tissues in mammals. It is regulated by hormones and various adipogenic transcription factors which are expressed as a transcriptional cascade to promote adipocyte differentiation, leading to the mature adipocyte phenotype. Recent findings indicated that microRNA （miRNA）, a family of small RNA molecules of approximately 22 nucleotides in length, were involved in the regulatory network of many biological processes, including cell differentiation, through post-transcriptional regulation of transcription factors and/or other genes. This review summarizes the recent progress about adipogenesis regulation of miRNAs with the proadipogenic or antiadipogenic factors manner in mouse, human and cattle. It may provide a useful reference for researcher＇s working in this field.
出处
《中国细胞生物学学报》
CAS
CSCD
2015年第1期106-114,共9页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:30800843)
重庆市教育委员会科学技术研究项目(批准号:KJ120605)
重庆师范大学2012年教改项目资助的课题~~
