摘要
目的探讨血塞通联合利伐沙班预防下肢骨折术后深静脉血栓(DVT)形成的疗效及对患者血液流变学的影响。方法 100例符合纳入标准的下肢骨折术后患者随机分为两组,每组各50例。对照组给予血塞通治疗;观察组在对照组的基础上联合使用利伐沙班治疗。疗程结束后,比较两组患者DVT发生率、DVT早期诊断指标及血液流变学情况。结果观察组DVT的发生率为8.0%,明显低于观察组44.0%的DVT发生率,两组相比较差异有统计学意义(P<0.05)。术后3天,与对照组相比,观察组DVT早期诊断指标D-dimer、同型半胱氨酸和CRP明显降低,比较差异有统计学意义(P<0.05)。血液流变学方面,观察组治疗后红细胞压积、全血黏度和纤维蛋白原较对照组明显降低,比较差异有统计学意义(P<0.05)。结论血塞通联合利伐沙班是预防下肢骨折术后DVT发生的有效方案,可以明显降低DVT发生率,显著降低DVT的早期诊断指标,并改善患者血液高凝状态,值得临床上进一步研究及推广。
【Objective】To investigate the clinical effect of xuesaitong injection in combination with rivaroxaban and its effects on hemorheology in the prevention of deep venous thrombosis（DVT） after operation of lower limbs fractures. 【Methods】A total of 100 cases with operation of lower limb fractures meeting the inclusion criteria were randomly divided into two groups with equal number. The cases in the control group were treated with xuesaitong injection while those in the observation group were treated with xuesaitong injection and rivaroxaban. The incidence of DVT, early diagnostic indices of DVT and hemorheology indices were observed and compared.【Results】The observation group had a total DVT incidence of 8.0%, which was statistically lower than that of 44.0% in the control group（P〈0.05）. Three days after the operation, D-dimer, homocysteine and CRP which reflect early diagnosis of DVT in the observation group were statistically lower than those in the control group（P〈0.05）. As to hemorheology indices, in comparison to the control group, hematocrit, whole blood viscosity and fibrinogen in the observation group were statistically lower（P〈0.05）.【Conclusions】After operation of lower limbs fractures, the treatment with a combination of xuesaitong injection and rivaroxaban for the prevention of DVT is reliable, which could significantly reduce the incidence of DVT, decrease early diagnostic indices of DVT and alleviate blood hyper-coagulation.
出处
《中国现代医学杂志》
CAS
北大核心
2015年第3期75-78,共4页
China Journal of Modern Medicine
关键词
血塞通
利伐沙班
下肢骨折
深静脉血栓
血液流变学
xuesaitong
rivaroxaban
lower limb fracture
deep venous thrombosis
hemorheology
