摘要
采用水热法制备了CdTe量子点（QDs）,并采用静电层层自组装技术成功制备了CdTe QDs聚二烯丙基二甲基氯化铵（PDDA）固化多层膜,建立了该固化多层膜测定抗凝药物华法林（Warfarin,WF）的荧光分析新方法。结果表明,在0.1∽10μmol/L范围内,相对荧光强度（F/F0）与华法林浓度（cWF）呈线性关系,相关系数（R2）和检出限（3σ/k）分别为0.9886和0.082μmol/L。该CdTe QDs/PDDA固化多层膜稳定性好、易储存、使用方便,可用于药物片剂中华法林含量的测定。
A novel method for the determination of warfarin was developed based on multilayer film of CdTe quantum dots（QDs）in this paper.With the electrostatic layer-by-layer self-assembly technology,the multilayer film of CdTe QDs/PDDA was successfully prepared.The multilayer film of CdTe QDs/PDDA was applied for rapid determination of anticoagulant warfarin.The results showed that the linear range of warfarin concentration was 0.1-10μmol/L.The linear correlation coefficient（R2）and detection limit（3σ/k）was 0.9886 and 0.082μmol/L,respectively.This multilayer film of determination warfarin is good stability,easy to store and convenient.The proposed method has been successfully applied for the determination of warfarin in tablets.It provided a simple and practicable assay sensor for determination of warfarin.
出处
《分析科学学报》
CAS
CSCD
北大核心
2014年第5期713-717,共5页
Journal of Analytical Science
基金
国家科技支撑计划(No.2010BAK67B12)
关键词
CDTE量子点
静电层层自组装
多层膜
华法林
CdTe quantum dots
Electrostatic layer-by-layer self-assembly
Multilayer film
Warfarin
