摘要
目的探讨广东地区汉族新生儿迁延性黄疸与UGT1A1基因Gly71Arg突变的关系。方法将新生儿分为迁延性黄疸组、母乳性黄疸组及正常对照组,对3组新生儿的总胆红素及UGT1A1基因Gly71Arg突变等情况进行统计对比分析。结果 3组的UGT1A1基因突变率及A等位基因频率差异有统计学意义(P<0.05),迁延性黄疸组Arg基因发生率与母乳黄疸组、正常对照组相比差异均有统计学意义(P<0.05),而母乳性黄疸组与正常对照组的UGT1A1基因突变率及A等位基因频率比较差异无统计学意义(P>0.05)。结论迁延性黄疸与UGT1A1基因Gly71Arg突变相关,而母乳性黄疸与之无关,携带A等位基因可能会增加新生儿出现迁延性的黄疸的风险。
Objective To observe the correlation between neonate persisting jaundice in Han population in Guangdong and Gly71 Arg mutation of UGT1A1 gene. Methods The newborns were selected and divided into persisting jaundice group,breast- feeding jaundice group and normal control group. The data,including total bilirubin and Gly71 Arg mutation,were collected for analysis. Results There were significant differences in genotype distribution and allelic gene A frequency among the three groups（P〈0. 05）. There were significant differences in Gly71 Arg mutation rate of UGT1A1 gene and allelic gene A frequency between persisting jaundice group and the other 2 groups（P〈0. 05）,but there was no difference between the breast- feeding jaundice group and the normal control group（P〉0. 05）. Conclusion The neonate persisting jaundice is correlated with UGT1A1 gene Gly71 Arg mutation,and carrying allelic gene A may increase the risk.
出处
《广东医学》
CAS
CSCD
北大核心
2014年第13期2016-2018,共3页
Guangdong Medical Journal
基金
广州市天河区科技计划项目(编号:201209KW014)
