摘要
目的:评价以奥硝唑或甲硝唑为基础治疗滴虫性阴道炎的临床疗效和安全性。方法:检索CNKI、VIP、CBM、Pub Med、EMBase、Cochrane library数据库(1985-2013年),收集奥硝唑与甲硝唑治疗滴虫性阴道炎的临床随机对照研究,筛选符合纳入标准的临床研究,应用Juni评分法进行评价,运用Rev Man 5.0软件对相关数据进行Meta分析,运用Stata11.0进行累积Meta分析。结果:根据标准筛选出20篇文献,2篇英文文献,18篇中文文献,累计病例和对照数分别为1 309和1 263。Meta分析结果显示:奥硝唑与甲硝唑比较,治疗滴虫性阴道炎有效率的差异有统计学意义[OR=6.23,95%CI(4.47,8.70),P<0.000 01]。在不良反应发生率方面,两种方案无显著性差异。结论:与甲硝唑比较,奥硝唑具有起效迅速、临床症状缓解快、有效率高等优点,是治疗滴虫性阴道炎的优选方案。
Objective： To evaluate the clinical effects of omidazole and metronidazole in the treatment of trichomonas vaginitis. Methods： Through searching CNKI, VIP, CBM, PubMed, EMBase and the Cochrane library database （from 1985 to 2013）, the random controlled clinical studies were retrieved about omidazole and metronidazole in the treatment of trichomonas vaginitis. The clinical studies screened according to criteria were evaluated by Juni scoring method, meta analysis was made on the relevant data using RevMan 5.0 software and Stata 11.0 was applied to cumulative meta analysis. Results： About 20 articles were selected according to the criteria, of which 2 articles was in English and 18 Chinese articles. The cumulative number of cases and controls were 1 309 and 1 263. The meta analysis results showed that the difference of efficiency rate through comparison of omidazole and metronidazole was statistical significance in the treatment of trichomonal vaginitis [OR=6.23, 95%CI（4.47, 8.70）, P 〈 0.000 01]. There was no significant difference in the incidence of adverse reactions. Conclusion： Compared with metronidazole, omidazole has advantages of fast onset of effect, easing symptoms quickly and a high effective rate. So ornidazole is a better choice for the treatment of trichomonas vaginitis.
出处
《中国执业药师》
CAS
2015年第2期31-35,共5页
China Licensed Pharmacist
