摘要
目的系统评价放置鼻胃管前使用利多卡因雾化剂的有效性和安全性。方法计算机检索Pub Med、EMbase、The Cochrane Library、Wan Fang Data、VIP、CBM和CNKI数据库,收集放置鼻胃管前使用利多卡因雾化剂的疗效和安全性的随机对照试验(RCT),检索时限均为从建库至2014年1月。由2位研究者按照纳入与排除标准独立筛选文献、提取资料和评价纳入研究的方法学质量后,采用Rev Man 5.2软件进行Meta分析。结果共纳入6个RCT,包括384例患者。Meta分析结果显示,与对照组相比,试验组在疼痛不适感[MD=–25.35,95%CI(–30.37,–24.33)]和一次性插管成功率[RR=1.38,95%CI(1.21,1.57)]方面更优,其差异均有统计学意义。结论鼻胃管放置前预防性应用利多卡因雾化剂可以减低患者的疼痛不适感,提高一次性插管成功率。
Objective To systematically review the efficacy and safety of intranasal lidocaine spray before nasogastric tube insertion. Methods We searched Pub Med,EMbase,The Cochrane Library,Wan Fang Data,VIP,CBM and CNKI databases concerning randomized controlled trial（RCT） of the efficacy and safety of intranasal lidocaine spray before nasogastric tube insertion from their inception to January 2014. Two reviewers independently screened literature according to the inclusion and exclusion criteria,extracted data,and assessed methodological quality of included studies. Meta-analysis was then conducted using Rev Man 5.2 software. Results Six RCTs involving 384 patients were included. The results of meta-analysis showed that there were no significant differences between the lidocaine group and the saline group in pain and discomfort scores（MD= –25.35,95%CI –30.37 to –24.33） and first successful insertion rate（RR=1.38,95%CI 1.21 to 1.57）. Conclusion Intranasal lidocaine spray before nasogastric tube insertion could reduce patient pain and discomforts related to the procedure,and improve the first successful insertion rate.
出处
《中国循证医学杂志》
CSCD
2015年第3期342-345,共4页
Chinese Journal of Evidence-based Medicine
基金
兰州大学第一医院院内基金(编号:lzdxdyyy-2013-13)
