摘要
目的:观察香砂养胃丸联合奥美拉唑对胃溃疡穿孔修补术后溃疡复发情况及胃黏膜血管内皮生长因子(VEGF)、碱性成纤维因子(b FGF)表达的影响。方法:将178例胃溃疡穿孔患者随机均分为对照组和观察组。两组患者术后均给予抗生素、抑酸、胃肠减压、肠外营养支持等常规治疗。在此基础上,对照组患者给予奥美拉唑肠溶胶囊20 mg,口服,bid;观察组患者在对照组治疗的基础上给予香砂养胃丸9 g,口服,bid。两组患者疗程均为8周。观察两组患者复发率及复发溃疡大小,治疗前后各临床症状评分,复发患者胃黏膜VEGF m RNA、b FGF m RNA的表达及不良反应发生情况。结果:观察组患者复发率显著低于对照组,溃疡平均直径显著小于对照组,两组比较差异均有统计学意义(P<0.05)。治疗前两组患者临床症状评分比较,差异均无统计学意义(P>0.05);治疗后两组患者临床症状评分均显著低于同组治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05)。观察组复发患者胃黏膜VEGF m RNA、b FGF m RNA的表达均显著高于对照组,两组比较差异均有统计学意义(P<0.05)。两组患者治疗期间均未见明显不良反应发生。结论:香砂养胃丸联合奥美拉唑可降低溃疡穿孔修补术后患者胃溃疡的复发率,减小复发溃疡直径,有效缓解症状,上调VEGF m RNA、b FGF m RNA的表达,且安全性较好。
OBJECTIVE：To observe the effect of Xiangsha yangwei pill on the expression of mucosal VEGF and b FGF of patients after gastric ulcer perforation repair. METHODS：A total of 178 patients with gastric ulcer perforation repair were randomly divided into control group and observation group. 2 groups were both given conventional treatment including antibiotics,acid suppression,gastrointestinal decompression and parenteral nutrition,etc. Based on it,control group was given omeprazole capsules 20 mg orally,twice a day for 8 weeks;observation group was given Xiangsha yangwei pills 9 g orally based on control group,twice a day for 8 weeks. The recurrence rate,ulcer size of recurrent patients,clinical symptom scores before and after treatment,expression of mucosal VEGF m RNA and b FGF m RNA and adverse reactions were observed. RESULTS：The recurrence rate in observation group was significantly lower than control group and the ulcer size of recurrent patients in research group was smaller than control group,with significant difference（P〈0.05）. There was no significant difference in the clinical symptom scores before treatment（P〈0.05）;after treatment,the clinical symptom scores in 2 groups were significantly lower than before,and observation group was lower than control group,with significant difference（P〉0.05）. Expression of mucosal VEGF m RNA and b FGF m RNA in recurrent patients in observation group were significantly higher than control group,with significant difference（P〈0.05）. There was no obvious adverse reaction during treatment. CONCLUSIONS：Xiangsha yangwei pill combined with omeprazole can reduce the recurrence rate of gastric ulcer after gastric ulcer perforation repair and recurrence ulcer size,relieve symptoms and increase the expression of VEGF m RNA and b FGF m RNA with better safety.
出处
《中国药房》
CAS
北大核心
2015年第9期1208-1210,共3页
China Pharmacy
关键词
胃溃疡
胃穿孔修补术
香砂养胃丸
奥美拉唑
Gastric ulcer
Gastric perforation repair
Xiangsha yangwei pill
Omeprazole
