摘要
目的探讨冠心病患者外周血高敏C反应蛋白(hs-CRP)、氧化型低密度脂蛋白(ox-LDL)和同型半胱氨酸(Hcy)水平及其意义。方法选取经冠状动脉造影检查证实冠心病组272例,分为急性心肌梗死(AMI)组105例,不稳定型心绞痛(UA)组126例,稳定型心绞痛(SAP)组41例;选取冠状动脉造影证实冠状动脉无狭窄病变56例为对照组。采集研究对象入院24小时内静脉血,ELISA法检测ox-LDL水平,日立7070型全自动生化分析仪测定hsCRP、Hcy、总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白(LDL)指标。结果冠心病组血清hs-CRP、ox-LDL、Hcy水平显著高于对照组,差异有统计学意义(P<0.01);AMI组血清hs-CRP、ox-LDL、Hcy水平显著高于SAP组,差异有统计学意义(P<0.05);AMI组血清hs-CRP、ox-LDL水平显著高于UA组,差异有统计学意义(P<0.05)。结论联合检测hs-CRP、ox-LDL、Hcy有助于对冠心病的诊断。
Objective To investigate the level and significance of peripheral high-sensitivity C-reactive protein（ hs-CRP）,oxidized low-density lipoprotein（ ox-LDL） and homocysteine（ Hcy） in patients with coronary heart disease. Methods 272 patients with coronary heart disease were selected,which confirmed by coronary angiography,including 105 cases of acute myocardial infarction（ AMI）,126 cases of unstable angina（ UA） and 41 cases of stable angina patients（ SAP）. The control group included 56 patients with no coronary artery stenosis confirmed by coronary angiography. Collected the fasting blood of patients within 24 hours of admission,the levels of ox-LDL was detected by ELISA,and the determination of hs-CRP、Hcy、total cholesterol,triglycerides,LDL index was detected by Hitachi 7070 automatic biochemical analyzer. Results The serum levels of hs-CRP、ox-LDL、Hcy in the grope of coronary heart disease were significantly higher than normal control group（ P〈0. 01）. The serum levels of hs-CRP、ox-LDL、Hcy in the grope of acute myocardial infarction were significantly higher than stable angina patients group（ P〈0. 05）. The serum levels of hsCRP、ox-LDL in the group of acute myocardial infarction were significantly higher than unstable angina group（ P〈0. 05）. Conclusions Combined detection may help clinical diagnosis of coronary artery disease.
出处
《心脑血管病防治》
2015年第1期4-5,11,共3页
CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
基金
河北省张家口市2013年科学技术研究与发展指令计划(编号:1311055D-3)
