摘要
目的:研究通心络胶囊对急性脑梗死合并2型糖尿病患者血脂及炎症因子的影响。方法:将154例急性脑梗死合并2型糖尿病患者随机分为联合组(52例)、辛伐他汀组(51例)与通心络组(51例)。3组患者均采用急性脑梗死常规治疗方案。辛伐他汀组加用辛伐他汀,通心络组加用通心络胶囊,联合组加用辛伐他汀与通心络胶囊。3组患者治疗4周后评价疗效。结果:治疗后,3组患者TC、TG、HDL-C及LDL-C较治疗前均有明显改善(P<0.01);治疗后,辛伐他汀组与通心络组TC、TG及LDL-C水平均高于联合组(P<0.01),而HDL-C水平低于联合组(P<0.01),通心络组TC及TG水平高于辛伐他汀组(P<0.05);治疗后,3组患者hs-CRP、TNF-α、IL-1及IL-6均较治疗前明显下降(P<0.01);辛伐他汀组与通心络组治疗后IL-1、IL-6、TNF-α及hs-CRP均明显高于联合组(P<0.01),辛伐他汀组IL-1、IL-6、TNF-α及hs-CRP水平均低于通心络组(P<0.05)。结论:通心络胶囊可减轻急性脑梗死后炎症反应,具有调节异常血脂的功能,与辛伐他汀联用治疗急性脑梗死合并2型糖尿病具有更好的效果。
Objective： To explore the clinical effect of Tongxinluo capsule on blood lipid and inflammatory factor in acute cerebral infarction patients with type2 diabetes mellitus（T2DM）. Methods： The 154 cases were randomly divided into combination group, simvastatin group and Tongxinluo group. Patients in the three groups all received the ACI conventional treatments. The simvastatin group was additional given simvastatin, while the Tongxinluo group added Tongxinluo capsule. Patients in the combination group were given simvastatin and Tongxinluo capsule based on the ACI conventional treatment. After 4 weeks＇ treatment,the clinical effects of these groups were observed. Results： After treatment, the levels of TC, TG, HDL-C and LDL-C in the three groups all improved（P0.01）. The levels of TC, TG and HDL-C of the simvastatin group and Tongxinluo group were higher than that of combination group（P0.01）, while the HDL-C was lower than combination group（P0.01）. The Tongxinluo group had higher TC and TG level than the simvastatin group（P 0.01）. The levels of hs-CRP, TNF-α, IL-1and IL-6 of all the groups decreased obiviously than before（P 0.01）. The simvastatin group and Tongxinluo group had higher IL-1, IL-6, TNF-αand hs-CRP than the combination group（P0.01）, whlie the four inflammatory factors in the simvastatin group were lower than that of Tongxinluo group（P0.05）. Conclusion： The Tongxinluo capsule has the advantage of improving the inflammatory response after ACI and adjusting the dyslipidemia, it shows better effects when combined with simvastatin.
出处
《中医药导报》
2015年第6期90-92,共3页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
关键词
急性脑梗死
2型糖尿病
通心络胶囊
辛伐他汀
血脂
炎症因子
Acute Cerebral Infarction（ACI）
Type 2 Diabetes Mellitus（T2DM）
Tongxinluo Capsule
Simvastatin
Blood Lipid
Inflammatory Factor
