摘要
磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)和丝裂原活化蛋白激酶(MAPK)通路是细胞内重要的信号转导通路。研究发现PI3K/Akt和MAPK信号通路经下游多种靶点,即内皮型一氧化氮合酶、糖原合成酶激酶3、核因子κB、细胞外信号调剂激酶等促进脑缺血后神经细胞的存活PI3K/Akt和MAPK这两条信号通路在缺血性脑损伤中发挥重要的作用,在一定条件下,这两条信号通路的激活可以通过上述途径有效抑制神经元细胞的凋亡而发挥脑保护的作用。
Phosphoinositide 3-kinase / protein kinase B（ PI3 K / Akt） and mitogen-activated protein kinases（ MAPK） signal pathways are important intracellular signaling transduction pathways. It has been reported that both of them could activate downstream targets,namely,endothelial nitric oxide synthase,glycogen synthase kinase3,nuclear factor-κB,extracellular signal regutated kinase,et al. to make the neurons survive after ischemia brain injury. Therefore,such findings indicate that PI3 K / Akt and MAPK signal pathways play critical roles in ischemia brain injury. Under certain circumstances,activation of these two pathways can effectively inhibit apoptosis of neuronal cells through the above ways and play a protective role in ischemia brain injury.
出处
《医学综述》
2015年第2期210-213,共4页
Medical Recapitulate
关键词
磷脂酰肌醇3-激酶/蛋白激酶B
丝裂原活化蛋白激酶
脑保护
脑缺血
凋亡
Phosphoinositide 3-kinase/protein kinase B
Mitogen-activated protein kinases
Cerebral protection
Cerebral ischemia
Apoptosis
