摘要
目的:分析低分子肝素对慢阻肺呼吸衰竭患者微循环及氧代谢状态的影响。方法:将120例慢阻肺并呼吸衰竭患者随机分为两组,对照组和观察组各60例。对照组采用基础治疗,观察组则加载低分子肝素治疗。比较治疗前后两组患者间肺功能指标、甲襞微循环指标和氧代谢状态指标差异。结果:治疗后3 d、7 d,观察组肺功能指标FEV1%、TLC、PIMAX和PEMAX显著高于对照组,而FRC则显著低于对照组;甲襞微循环指标管襻形态积分、血流状态积分、襻周状态积分、总积分显著低于对照组,而毛细血管流速则显著快于对照组;氧代谢状态指标Ca O2、DO2、Pa O2显著高于对照组,而VO2和Ca-v O2则显著低于对照组,P<0.05。结论:低分子肝素通过降低慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)并呼吸衰竭患者的血液黏度,增加肺部血流供应,从而促进肺功能的提高,并表现为氧代谢相关指标的改善。
Objective：To observe the influence of low molecular weight heparin for the microcirculation and oxygen metabolic state of patients with chronic obstructive pulmonary disease（COPD） combined with respiratory failure. Methods ：120 cases of patients with COPD combined with respiratory failure were randomly divided into control group and observation group,each group had 60 cases. Patients in control group were taken basic treatment programs, and those in observation group were treated combined with low molecular weight heparin. Then the indicators of lung function,microcirculation indicators and oxygen metabolic state of two groups before and af- ter treatment were detected and compared. Results：After 3 and 7 days of treatment, the indicators of lung function such as FEV1% , TLC, PIMAX and PEMAX of observation group were higher than control group, while the FRC was lower than control group ; and indica- tors Of mierocirculation indicators pipe loop integral points,blood flow points,loop weeks status points,total score of observation group were lower than control group,while the capillary flow rate was significantly faster than the control group;and the indicators of oxygen metabolic state such as CaO2 , DO2 , PaO2 of observation group were higher than those of control group, while the VO2 and Ca-vO2 were lower than those of control group, all P 〈 0. 05. Conclusion：Low molecular weight heparin can effectively reduce the blood viscosity in patients with COPD combined with respiratory failure,and increase the blood supply to pulmonary,helping to improve lung function and oxygen metabolism related indicators.
出处
《川北医学院学报》
CAS
2015年第1期105-108,共4页
Journal of North Sichuan Medical College
关键词
慢性阻塞性肺疾病
呼吸衰竭
低分子肝素
微循环
氧代谢
Chronic obstructive pulmonary disease
Respiratory failure
Low molecular weight heparin
Microcirculation
Oxy-gen metabolic
