摘要
目的:评价中药复方丹金丸治疗非酒精性脂肪性肝病的疗效,分析超声声像图分度变化与疗效的相关性。方法:将60例非酒精性脂肪性肝病患者随机分为治疗组(40例)和对照组(20例),治疗组予中药复方丹金丸口服,对照组予安慰剂口服。2组疗程均为3个月,观察治疗前后肝脏超声声像图分度变化、中医证候疗效、中医证候总积分改善情况,并对前二者行相关性分析。结果:1疗程结束后,共59例完成临床观察,治疗组40例,对照组19例。2治疗前后组内比较,治疗组肝脏超声声像图分度差异有统计学意义(P<0.05),而对照组差异无统计学意义(P>0.05);组间治疗后比较,2组肝脏超声声像图分度差异有统计学意义(P<0.05),治疗组超声声像图分度改善优于对照组。3治疗前后组内比较,治疗组中医证候总积分差异有统计学意义(P<0.05),而对照组差异无统计学意义(P>0.05);组间治疗后比较,2组中医证候总积分及积分差值差异均有统计学意义(P<0.05)。4治疗组、对照组总有效率分别为85.00%、57.89%;组间中医证候疗效比较,差异有统计学意义(P<0.05)。5中医疗效(痊愈、显效、有效、无效)与治疗前后肝脏超声声像图分度(正常、轻度、中度、重度)呈显著正相关性(P<0.05)。结论:中药复方丹金丸治疗"痰浊瘀结型"非酒精性脂肪性肝病疗效满意,超声检查及其声像图分度变化可作为本病疗效评价的主要方法及指标。
Objective：To observe the ultrasonic effection and its correlation with syndrome effectiveness of Chinese medicine compound Danjin pill treating non- alcoholic fatty liver disease. Method：Took 60 patients of non-alcoholic fatty liver disease into two groups,treating group of 40 patients treating by Chinese medicine compound Danjin pill and control group of 20 patie-nts treating by placebo for 3 months randomly. After the treatment,we observed the changes of liver ultrasonic ultrasonographic indexing,syndrome effectiveness and total points of syndrome,then researched the correlation between the ultrasonic effection and syndrome effectiveness. Result：1There were 59 patients completing the clinical observation,40 of treating group and 19 of control group after the treatment. 2the Liver ultrasonic ultrasonographic indexing was significantly different from before the treatm-ent in treating group（P 0.05）,and it was not significantly different from before the treatment in control group（P 0.05）. After the treatment,there was a significant difference of the liver ultrasonic ultrasonographic indexing between the two groups（P 0.05）.The treating group＇s changes surpassed the control group. 3Total points of syndrome was significantly different from before the treatment in treating group（P 0.05）,and it was not significantly different from before the treatment in control group（P 0.05）.After the treatment,there was significant difference of total points of syndrome between the two groups（P 0.05）. 4Total effective rate of treating group was 85.00% and 57.89% of control group. There was significant difference of syndrome effectiveness between the two groups（P 0.05）. 5There was a significant positive correlation between the syndrome effectiveness（be cured,markedly,effective,invalid） and the changes of liver ultrasonic ultrasonographic indexing（normal,mild,moderate,severe）（P 0.05）.Conclusion：Compound Danjin pill can treat phlegm and blood stasis syndrome non-alcoholic fatty liver disease with great effection. Ultrasound examination may can be the main method and index to assess the effection in clinic and scientific research to treat this disease.
出处
《中国中西医结合影像学杂志》
2015年第1期37-39,43,共4页
Chinese Imaging Journal of Integrated Traditional and Western Medicine
基金
湖南省中医药科研基金(2008035)
关键词
脂肪肝
复方丹金丸
痰浊瘀结证
超声检查
统计学
非参数
Fatty liver
FUFANG DANJIN WAN
Phlegm and blood stasis syndrome
Ultrasonography
Statistics
nonparametric
