摘要
目的:通过对酵母样真菌的系统鉴定,分析医院酵母样真菌感染情况及耐药现状,以指导临床合理用药,为减少真菌感染提供试验依据。方法:将各种临床标本分离培养后使用法国VITEK 2 Compact全自动微生物鉴定仪、酵母菌鉴定卡及ATB Fungus 3药敏板进行真菌鉴定和药敏试验。结果:共检出院内酵母样真菌感染210例,以假丝酵母菌为主(占97.14%),其中白色假丝酵母菌140株(占66.67%),热带假丝酵母菌30株(占14.29%)。对伊曲康唑的敏感率最低仅为53.3%,对氟康唑、伏立康唑、卡泊芬净、5-氟胞嘧啶和米卡芬净的耐药率均<7%,两性霉素B耐药率为0%。结论:假丝酵母菌是院内感染最常见的酵母样真菌,耐药性有增长趋势,故应加强真菌的分离、鉴定以及耐药性监测,以指导临床合理选择药物。
Objective： Through the system identification of yeast-like fungus, analyze hospital infection and drug-resistant to guide clinical therapy, in order to reduce fungal infections provide the experimental basis. Methods： After the isolation and culture of various clinical specimens, tests of fungi identification and drug sensitive were performed by using VITEK 2 Compact Automated microbial identification system, Yeast identification card, ATB Fungus 3 fungal produced by the France BioMerieux company. Results： In 210 strains, yeast-like fungal infections were isolated, with Candida, accounting for 97.14%, of which a maximum of Candida albicans, 66.67%, followed by Candida tropical 14.29%. Sputum was detected fungi most, accounting for 27.62%, mainly in elderly patients. The Sensitive rate of itraconazole was lowest, only 53.3%, fluconazole, voriconazole, caspofungin, 5-fluorocytosine and micafungin resistance rates all lower than 7%, amphotericin B resistance rate was 0. Conclusion： Candida was the most common infection yeast-like fungi, there were increasing trend of drug resistance. It should strengthen the separation of fungus, identification and monitoring of drug resistance to guide clinical rational drug of choice.
出处
《中国医学装备》
2015年第3期67-70,共4页
China Medical Equipment
关键词
酵母样真菌
系统鉴定
耐药性
阿萨希毛孢子菌
Yeast-like fungus
Systematic identification
Drug-resistace
Trichosporon asahii
