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Intermediate conductance, Ca^2＋-activated K^＋ channels： a novel target for chronic renal diseases

Intermediate conductance, Ca^2＋-activated K^＋ channels： a novel target for chronic renal diseases
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摘要 Renal failure is a medical condition in which the kidneys are not working properly. There are two types of kidney failure： 1） acute kidney failure, which is sudden and often reversible with adequate treatment; and 2） chronic renal failure, which develops slowly and often is not reversible. The last stage of chronic renal failure is fatal without dialysis or kidney transplant. The treatment for chronic renal failure is focusing on slowing the progression of kidney damage. Several reports have described a promising approach to slow the loss of renal function through inhibition of the basolateral membrane, Ca^2＋-activated K^＋ （KCa3.1） channel with a selective and nontoxic blocker TRAM-34. This review summarizes pathophysiological studies that describe the role of KCa3.1 in kidney diseases. Renal failure is a medical condition in which the kidneys are not working properly. There are two types of kidney failure： 1） acute kidney failure, which is sudden and often reversible with adequate treatment; and 2） chronic renal failure, which develops slowly and often is not reversible. The last stage of chronic renal failure is fatal without dialysis or kidney transplant. The treatment for chronic renal failure is focusing on slowing the progression of kidney damage. Several reports have described a promising approach to slow the loss of renal function through inhibition of the basolateral membrane, Ca^2＋-activated K^＋ （KCa3.1） channel with a selective and nontoxic blocker TRAM-34. This review summarizes pathophysiological studies that describe the role of KCa3.1 in kidney diseases.
作者 Claudia A. BERTUCCIO Daniel C. DEVOR
机构地区 Department of Cell Biology School of Medicine
出处 《Frontiers in Biology》 CAS CSCD 2015年第1期52-60,共9页 生物学前沿（英文版）
关键词 Ca^2＋-activated K^＋ channels KCa3.1 renal fibrosis polycystic kidney disease diabetes nephropathy transplant cell proliferation C1 secretion renal failure Ca^2＋-activated K^＋ channels, KCa3.1, renal fibrosis, polycystic kidney disease, diabetes nephropathy, transplant,cell proliferation, C1 secretion, renal failure
分类号 S277.525 [农业科学—农业水土工程] S858.31 [农业科学—临床兽医学]
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Frontiers in Biology
2015年 第1期

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