摘要
富血小板凝胶是近年来新出现的辅助治疗糖尿病足溃疡（DFU）的方法之一.局部应用富血小板凝胶治疗DFU可有效改善DFU的难愈合性并提高溃疡愈合率,且无明显不良反应发生;也可降低截肢率,且没有增加医疗总费用.富血小板凝胶治疗DFU的作用机制可能与其中富含的生长因子、细胞因子和白细胞等有关,还可能与凝胶超微结构、溃疡中基质金属蛋白酶的变化有关.
Platelet-rich gel is one of the new adjuvant therapies of diabetic foot ulcer （DFU）.The topical application of platelet-rich gel is efficient in reversing the nonhealing character and improving the outcomes of DFU,with no serious adverse events.It also reduces the amputation risk of lower limbs without increasing the total medical expenditure.Platelet-rich gel is rich in growth factors,cytokines and white blood cells,which may be the underlying mechanism for its efficiency in DFU treatment;moreover,the special ultrastructure and the stimulation of matrix metalloproteinase in the ulcers may also helpful for the growth of ulcer tissue.
出处
《国际内分泌代谢杂志》
2015年第2期130-132,共3页
International Journal of Endocrinology and Metabolism
关键词
富血小板凝胶
糖尿病
糖尿病足溃疡
Platelet-rich gel
Diabetes mellitus
Diabetic foot ulcer
