摘要
目的:比较异维A酸和阿维A治疗扁平疣的疗效及对IL-2和sIL-2R水平的影响。方法:110例扁平疣患者随机分为A组和B组,各55例,A组口服异维A酸胶丸,B组口服阿维A胶囊,共治疗6周。采用ELISA法检测IL-2和sIL-21水平变化并观察临床疗效。结果:A、B组痊愈率分别为68.51%和64.15%,无显著性差异(P>0.05);6个月复发率分别为5.56%和7.55%,无显著性差异(P>0.05);两组患者治疗后IL-2水平提高,sIL-2R水平下降,与治疗前比较差异有显著性(P<0.05)。A、B组IL-2和sIL-2R水平变化无显著性差异(P>0.05);结论:异维A酸胶丸和阿维A胶囊治疗扁平疣均有好疗效。
Objective：To compare the efficacy and changes in IL-2 and sIL-2R levels of isotretinoin and acitretin in the treatment of verruca plana.Methods：One hundred and ten patients with verruca plana were randomly divided into the group A and group B （55 patients in each group）.The patients in group A were treated with isotretinoin and those in group B were treated with acitretin.The course of the treatment was 6 weeks in both groups.The levels of IL-2 and sIL-2R were detected by ELISA and the therapeutic efficacy was clinically assessed.Results：The cure rates of group A and group B were 68.51％ and 64.15％ respectively,with no significant difference （P＞0.05） ;the recurrence rates were 5.56％ and 7.55％ after follow-up for 6 months,with no significant difference （P＞0.05）.Compared with the levels of the IL-2 and sIL-2R before the treatment,the level of IL-2 increased and that of sIL-2R declined after the treatment,with significant differences （P＜0.05）.There was no significant differences in the changes in IL-2 and sIL-2R levels between the group A and the group B （P＞0.05）.Conclusion：Isotretinoin and acitretinhave equivalent efficacy in the treatment of verruca plana.
出处
《中国麻风皮肤病杂志》
2015年第2期94-96,共3页
China Journal of Leprosy and Skin Diseases
