摘要
随着分子诊断技术的发展，白血病的病因学已从群体医学、细胞生物学进入分子生物学的研究。分子诊断技术在白血病的诊断、预后判断及个体化治疗中应用日益广泛，正逐渐成为白血病患者必需的常规检测项目之一。迄今为止，白血病在分子诊断领域的各类检测方法从细胞遗传学诊断，到分子遗传学诊断，再到PCR分子诊断和各种突变检测以及新一代测序，这些技术在白血病的诊断、微小残留病的监测、预后判断及靶向治疗等方面发挥了重要的作用。
With the development of molecular diagnostic techniques, the study for the etiology of leukemia has been entering the era of the molecular biology. Molecular techniques for leukemia diagnosis, prognosis and individualized therapy are used widely, becoming one of the necessary routine tests for patients with leukemia. So far, molecular techniques for leukemiaincluding cytogenetic diagnosis, molecular genetics, molecular diagnostics based on PCR, mutation detection, as well as a variety of next-generation sequencing, have played an important role in the diagnosis of leukemia, minimal residual disease monitoring, prognosis and targeted therapy. （Chin J Lab Meal,2015,38：206-210）
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2015年第3期206-210,共5页
Chinese Journal of Laboratory Medicine
基金
国家临床重点专科建设项目（财社[2010]305号）
关键词
白血病
分子诊断技术
Leukemia
Molecular diagnostic techniques
