期刊文献+

儿童紫癜性肾炎流行病学、发病机制及相关生物学指标研究进展 被引量:14

在线阅读 下载PDF
导出
摘要 过敏性紫癜(HSP)是儿童时期最常见的一种以非血小板减少性紫癜为特征性临床表现的系统性小血管炎症,可引起不同的临床表现,包括皮肤紫癜、腹痛、关节炎及紫癜性肾炎(HSPN)等。在HSP患者中HSPN的发生率为30%~50%,极少部分进展为慢性肾脏疾病,肾脏受损的严重程度决定了患者的病程及临床预后。有研究表明,可以通过血清中基质金属蛋白酶-9、正五聚蛋白-3、平滑肌肌动蛋白等生物学指标对HSPN进行早期诊断和预测肾损伤的严重程度。本文对HSPN的流行病学、发病机制及相关生物学指标的研究进展予以综述。
出处 《新乡医学院学报》 CAS 2015年第4期364-366,共3页 Journal of Xinxiang Medical University
基金 河南省科技厅科技发展计划项目(编号:11210231020)
  • 相关文献

参考文献31

  • 1Gardner-Medwin J M, Dolezalova P, Cummins C,et al, Incidence of Henoch-Schfinlein purpura, Kawasaki disease, and rare vasculitides in children of different ethnic origins [ J ]. Lancet, 2002, 60 (9341) : 1197-1202.
  • 2Calvino M C, Llorea J, Garcia-Porrua C, et al. Henoeh-Sehfinlein purpura in children from northwestern Spain:a 20-year epidemio- logic and clinical study [ J ]. Medicine : Baltimore, 2001 , 80 ( 5 ) : 279-290.
  • 3Saulsbury F T. Henoeh-Sch,nlein purpura in children-Report of 100 patients and review of the literature [ J ]. Med&ine, 1999,78 (6) :395-409.
  • 4Saulsbury F. Henoch-Schinlein purpura [ J]. Curr Opin Rheuma- tol,2010,22(5) :598-602.
  • 5Kawassaki Y, Suyama K, Yugeta E, et al. The incidence and severi- ty of Henoch-Schtinlein purpura nephritis over a 22-year period in Fukushima Pzefceture Japan[ J ]. Int Urol Nephrol, 2010,42 (4) : 1023-1029.
  • 6Gharavi A G, Kiryluk K, Choi M, et al. Genome-wide association study identifies susceptibility loci for IgA nephropathy [ J ]. Nat Genet ,2011,43(4) :321-327.
  • 7Yu X Q,Li M,Zhang H,et al. A genome-wide association study in Hart Chinese identifies multiple susceptibility locl for IgA ncphrop- athy [ J ]. Nat Genet,2012,44 ( 2 ) : 178-182.
  • 8Kiryluk K,Moldoveanu Z,Sanders J T,et al. Aberrant glycosylation of IgA1 is inherited in both pediatric IgA nephropathy and Henoch- Schtinlein purpura nephritis [ J ]. Kidney Int,2011,80 ( 1 ) :79-87.
  • 9Hisano S, Matsoshita M, Fujita T,et al. Activation of the lectin com- plement pathway in Henoch-Sch,nlein purpura nephritis[ J ]. Am J Kidney Dis,2005,45 ( 2 ) : 295-302.
  • 10Novak J, Vu H L, Nova k L,et al. Interactions of human mesangial cells with IgA and IgA-containing immune complexes[ J]. Kidney lnt, 2002,62 ( 2 ) :465-475.

二级参考文献8

  • 1黎磊石,关天俊,刘志红,俞雨生,唐政,陈惠萍,王庆文,姚小丹.4298例成年人肾小球疾病病理类型及流行病学特点[J].肾脏病与透析肾移植杂志,1997,6(2):103-109. 被引量:160
  • 2Churg J,Sobin LH. Renal disease-classification and at las of glomerula disease[M].Tokyo:lgaku.Shoin Medical Publishs Inc,1982.4-5.
  • 3Churg J,Bemstein J,Glassock RJ. Renal disease-Classification and at las of glomerula disease[M].New York:Igaku-shoin Medical Publishs Inc,1995.4-5.
  • 4中华医学会儿科学分会肾病学组.我国小儿肾小球疾病肾组织病理改变 (2 315例肾活检材料的综合分析)[J]中华儿科杂志,1995(34):319-323.
  • 5Rivera F,Lopez-Gomez JM,Perez-Garcia R. Frequency of renal pathology in Spain 1994-1999[J].Nephrology Dialysis Transplantation,2002,(09):1594-1602.
  • 6Simpson AK,Wong W,Morris MC. Paediatric nephritic syndrome in Auckland,New Zealand[J].Journal of Paediatrics and Child Health,1998,(04):360-362.
  • 7Mubarak M,Lanewala A,Kazi JI. Histopathological spectrum of childhood nephritic syndrome in Pakistan[J].Clin ExpNephrol,2009,(06):589-593.
  • 8刘光陵,高远赋,夏正坤,樊忠民,任献国,茅松,何旭,孙涛.2551例患儿肾小球疾病病理类型分析及其临床意义[J].医学研究生学报,2011,24(3):294-297. 被引量:15

共引文献9

同被引文献145

引证文献14

二级引证文献98

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部