摘要
刺激响应型纳米药物递送系统是一种功能性纳米给药系统.刺激响应脂质体不仅提供定位化学治疗,而且还具有控制释放药物的潜能,因此对于实施控制治疗肿瘤具有重要意义.当脂质体在特殊环境(包括热、光、磁和p H等)刺激下,可通过载体微观结构发生变化释放药物.刺激响应脂质体的优势是可减少或避免药物过早释放,提高靶向部位的释药效率.本文介绍了刺激响应脂质体的结构、特性和功能,分别综述了热、光、磁、p H刺激响应和p H-温度双刺激响应脂质体的特性,并讨论了刺激释药的机制.
Stimuli-responsive liposomes are a promising class of nanomedicine with the potential to provide site-specific chemotherapy. The liposomes have the potential not only to provide site-specific chemotherapy, but also to trigger drug release. Thus it is greater spatial and temporal control in the therapy. Their structure, configuration and other characteristics can be changed under certain in vivo or in vitro stimulus, including heat, light, magnetism and pH changes, and finally carried drugs in the liposome can be released. They can reduce or avoid premature drug release before the liposome reach target site and improve drug release efficiency at target sites. The structure, features and functions of the stimulus response liposomes are summarized. The relative thermal, light, magnetism and pH stimuli responsive properties are reviewed, and the mechanism of stimulate release drug are discussed.
出处
《中国科学：化学》
CAS
CSCD
北大核心
2015年第4期340-349,共10页
SCIENTIA SINICA Chimica
基金
国家自然科学基金(21073063
21273073
21473055)资助
关键词
刺激响应
脂质体
控制释放
药物载体
stimulation response, liposomes, control release drug, drug carrier
