摘要
五羟色胺(5-hydroxytryptamine,5-HT)又称为血清素(serotonin)广泛存在于机体多种组织。神经系统内的五羟色胺属于单胺类神经递质,与很多生理功能有关,参与对摄食、性行为、神经内分泌、疼痛感知、学习记忆和情绪、睡眠-觉醒等生理过程的调控。新近基于电生理、神经化学、分子生物学和神经药理学研究方法发现,五羟色胺和睡眠觉醒过程特别是觉醒过程密切相关,在促进觉醒、抑制快动眼睡眠方面有重要作用。本文介绍了五羟色胺在睡眠-觉醒周期中作用研究的最新进展。
5-HT（5-hydroxytryptamine） also known as serotonin, is exists variety of organizations in the body. The 5-HT of nervous system is belong to single amine neurotransmitter, associated with many physiological functions, participation of ingestion, sex,neuroendocrine, pain perception, learning and memory, emotion and sleep-awake regulation. Now, the methods of electrophysiology,neural chemistry, molecular biology, and neuropharmacology demonstrated serotonin is especially closely related to the awake of sleep and sleep process,it has an important role in promotion of awake, inhibition of Rapid Eye Movement sleep quickly. This paper introduces the latest progress of 5- HT and sleep-wake cycle.
出处
《现代生物医学进展》
CAS
2015年第11期2191-2194,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81371510)
