摘要
目的:探讨FOLFOX方案治疗胃癌的疗效及对血清干扰素-γ(INF-γ)和白细胞介素-4(IL-4)水平的影响。方法:选择我院2011年1月至2014年1月收治的胃癌患者80例,按随机数字表法平均分为两组,研究组及对照组各40例,以3周为1个疗程,治疗3个疗程。研究组患者给予FOLFOX方案治疗,对照组患者给予ELF化疗方案,3个疗程后,比较两组患者治疗有效率,同时比较两组患者治疗前后血清INF-γ和IL-4水平变化及不良反应发生情况。结果:3个疗程后,研究组患者治疗有效率为57.5%,明显高于对照组37.5%,比较差异具有统计学意义(P<0.05)。两组患者治疗后血清INF-γ水平及INF-γ/IL-4值较治疗前明显升高,而IL-4水平较治疗前明显下降,且研究组患者两种细胞因子水平改善程度均明显优于对照组,比较差异具有统计学意义(P<0.05)。研究组患者白细胞减少、血小板下降及恶心呕吐不良反应发生率分别为22.5%、7.5%及27.5%,与对照组25.0%、10.0%及32.5%,比较差异无统计学意义(P>0.05)。结论:FOLFOX方案治疗胃癌效果显著,可有效改善患者机体免疫水平,提高抗肿瘤效果,值得临床推广应用。
ABSTRACT Objective： TO investigate the curative effect of FOLFOX regimen in treatment of patients with gastric cancer and its effect on levels of serum interferon gamma （INF-γ） and interleukin -4（IL-4）. Methods： A total of 80 patients with gastric cancer, admitted to the Affiliated Tumor Hospital of Xinjiang Medical University from January 2011 to January 2014, were randomly divided into study group（n=40） and control group（n=40）. The study group was treated with FOLFOX regimen for 9 weeks（3 weeks was a course ）; while the control group was treated with ELF chemotherapy for 9 weeks. After 3 courses of treatment, the effective rates, levels of serum 1NF-3, and IL-4 before and after treatment, and incidence of adverse reactions of the two groups were compared. Results： After 3 courses of treatment, the effective rate （57.5%） of the study group was significantly higher than that （37.5%） of the control group, with significant difference （P〈0.05）. Compared with before therapy, serum INF-γ and INF-γ / IL-4 values of the two groups were significantly increased after treatment, but level of IL-4 decreased, and improvement of the two kinds of cytokines levels in the study group was significantly better than that of the control group, with significant difference （P〈0.05）. The adverse reaction rate of leukopenia, thrombocytopenia and nausea/vomiting of the study group was 22.5%, 7.5% and 27.5% respectively; of the control group, 25%, 10.0% and 32.5% respectively. There was no significant difference between the two groups （P〉0.05）. Conclusion： FOLFOX regimen has a significant effect in the treatment of patients with gastric cancer,which can effectively improve the immune level of the body, enhance the anti-tumor effect and is worthy of clinical application.
出处
《现代生物医学进展》
CAS
2015年第12期2316-2318,2396,共4页
Progress in Modern Biomedicine
