摘要
骨支架作为种子细胞和生长因子的载体,是骨组织工程修复的关键。骨支架的材料特征及微结构对其力学性能及种子细胞黏附和增殖等有重要影响。关于支架的制备,可以采用常规致孔技术形成多孔材料,也可以用快速成型等方法制成预先设计好的结构,还有直接利用动物骨衍生得到的支架。不同方法得到的支架内部微结构会有很大差别,支架的力学性能也自然不同,修复效果也各异。本文综述了近年来骨支架材料及微结构对其力学性能、种子细胞、组织修复影响的主要研究成果。
To serve as carriers of cells and bioactive molecules,three-dimensional scaffolds play a key role in bone defect repair.The chemical component and microstructure of the scaffold can affect the mechanical properties and seed cells.A variety of fabrication techniques have been used in producing scaffolds,some made random porous structure,some created well-designed structure using rapid prototyping methods,and others prepared bio-derived materials as scaffolds.However,scaffolds may vary in their inner structure,mechanical properties and repairing efficiency as well because of different manufacturing methods.In this review,we overview the main achievements concerning the effects of material and microstructure on the mechanical performance,seed cells and defect repair of bone scaffolds.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2015年第2期480-484,共5页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目(11322223
81471753)
教育部新世纪优秀人才支持计划资助项目(NCET-12-0024)
关键词
骨支架材料
微结构
力学性能
种子细胞
组织修复
bone scaffold material
microstructure
mechanical property
seed cell
tissue repair
