摘要
目的:回顾性分析492例肝硬化患者合并胆囊结石的发生率、临床特点及其相关影响因素,探讨肝硬化与胆囊结石的关系,为预防及临床治疗提供理论及治疗依据.方法:本研究将492例肝硬化患者分为两组,分别为:观察组(105例)为肝硬化合并胆囊结石组,对照组(387例)为肝硬化无胆囊结石组.并设立正常对照组(412例)为同期石河子大学第一附属医院健康体检并行腹部B超检查者为正常对照组.分析及比较两组各组间患者在年龄、性别、肝硬化病因、Child-Pugh分级、血浆白蛋白水平、血小板、总胆红素、直接胆红素、间接胆红素、载脂蛋白A、甘油三脂、高密度脂蛋白、总胆汁酸等指标之间的差异.结果:观察组及肝硬化合并胆囊结石的发生率为21.3%,明显高于正常对照组的单纯性胆囊结石发生率(5.6%).不同病因之间比较,乙型肝炎肝硬化患者合并胆囊结石发病率明显增高.单变量分析显示观察组和对照组在肝功能分级、直接胆红素、载脂蛋白A、高密度脂蛋白、甘油三脂相比差异均具有统计学意义(均P<0.05).结论:肝硬化患者易合并胆囊结石,肝功能C h i l d-P u g h分级、直接胆红素、载脂蛋白A、高密度脂蛋白、甘油三脂水平是肝硬化并发胆囊结石的危险因素.
AIM： To investigate the prevalence of and risk factors for gallstones in a large series of patients with cirrhosis. METHODS： Clinical data for 492 patients with liver cirrhosis treated at the First Affiliated Hospital of Shihezi University from January 2009 to January 2013 were retrospectively analyzed.Of these patients, 105 with gallbladder stones comprised an observation group, and 387 without gallbladder stones were included in a control group. A normal control group consisting of 412 healthy volunteers was also included. Clinical characteristics and possible risk factors were compared between different groups. RESULTS： The incidence of gallstones in patients with cirrhosis was 21.3%, significantly higher than that in the general population（5.6%）. Univariate analysis showed significant differences between the observation group and the control group with regard to Child-Pugh class, direct bilirubin, apolipoprotein A, high density lipoprotein, and triglycerides（P〈0.05）. CONCLUSION： In cirrhosis patients, Child-Pugh classification, direct bilirubin, apolipoprotein A, high density lipoprotein, and triglyceride levels are risk factors for gallstones.
出处
《世界华人消化杂志》
CAS
2015年第8期1308-1313,共6页
World Chinese Journal of Digestology
关键词
肝硬化
胆囊结石
发生率
危险因素
Liver cirrhosis
Gallstones
Incidence rate
Risk factor
