摘要
咳嗽变异性哮喘的发病机制及病理生理与典型哮喘相似,均以持续气道炎症、气道高反应性和气道重构为特点,平均约有30%的患儿最终发展为典型哮喘。近年来随着病理学的发展,发现哮喘患者发作期和缓解期均存在气道内炎症细胞浸润和炎性介质增多,提出了哮喘是一种气道慢性炎症性疾病的概念。气道炎症是气道重塑等病理发展的关键,现代医学研究认为,咳嗽变异性哮喘气道炎症机制复杂。明确有关炎症细胞及炎性介质在气道炎症机制中所起的作用或影响,可提高对本病的认识,及早干预,阻止病情进一步发展。
Cough Variant Asthma（ CVA）,is one special type of asthma,which behaves as cough as the only or the main clinical manifestations. It shows continuous airway inflammation,airway hyperresponsiveness and airway remodeling as characteristics,whose pathogenesis and pathological physiology are similar to typical asthma. There is an average of about 30% of children with CVA evolving into typical asthma. In recent years,with the development of pathology,one concept that the airway of the asthma is a chronic inflammatory disease is put forward,having found that inflammation of cells infiltration and mediators increasing in asthma patients during the stage of episodes and remission.Airway inflammation is the key to the development of pathology,such as airway remodeling. In order to improve the understanding of the inflammatory cells and disease,this article will present a description of the effect and Influence about inflammatory mediators in CVA mechanism of airway inflammation,so as to find effective method for early intervention of the disease,preventing further development.
出处
《长春中医药大学学报》
2015年第2期414-417,共4页
Journal of Changchun University of Chinese Medicine
基金
江苏省中医药局基金项目"黄龙止咳口服液治疗小儿咳嗽变异性哮喘风热夹痰症的临床及实验研究"(LZ13100)
关键词
儿童
咳嗽变异性哮喘
气道炎症
气道重塑
children
cough variant asthma
airway inflammation
airway remodeling
