摘要
目的探讨盐酸美金刚在改善帕金森痴呆患者认知功能和日常生活能力的治疗效果,为帕金森痴呆患者的诊治提供理论依据。方法选取宁波市第二医院收治的90例帕金森病痴呆患者作为研究对象,根据患者入院顺序编号,采用计算机随机抽签分组方法将90例患者随机分为观察组和对照组,对照采用盐酸多奈哌齐片治疗,观察组采用盐酸美金刚片治疗,在治疗时和治疗4、8、12周分别用简易智能精神状态检查量表(MMSE)和蒙特利尔认知评估量表(Mo CA)评价2组患者精神状态和认知功能,治疗结束后采用Barthel指数评估量表评定2组患者日常生活能力,治疗期间统计2组患者药物不良反应发生情况,采用SPSS 18.0软件包对所得的数据进行统计学分析。结果观察组和对照组治疗前MMSE、Mo CA评分差异无统计学意义(P>0.05),观察组在治疗4、8、12周MMSE和Mo CA评分均高于对照组,2组比较差异有统计学意义(P<0.05);观察组日常生活能力满意度为88.89%,明显高于对照组66.67%的满意度,2组比较差异有统计学意义(P<0.05);观察组药物不良反应发生率为17.78%,对照组药物不良反应发生率为20.00%,经统计学分析,2组间差异不存在统计学意义(P>0.05)。结论盐酸美金刚治疗帕金森痴呆对患者认知功能和日常生活能力改善较为显著,具有较高的临床治疗效果,值得在临床中推广。
Objective To study of the utility of memantine hydrochloride in improving cognitive function and daily life quality of patients with parkinsonism dementia. Methods A total of 90 patients with parkinsonism dementia were enrolled and randomly divided into observation group and control group. Donepezil hydrochloride tablets were administrated in the control group,while Memantine hydrochloride tablets in the observation group. On 0,4,8 and 12 weeks,The mini mental state examination scale（ MMSE） and the Montreal cognitive assessment scale（ Mo CA） were used to assess the mental status and cognitive function of patients,Barthel index assessment scale was employed to evaluated the daily life ability evaluation of patients after the treatment. The incidence of medicine adverse reactions during the procedure was observed. The data was analyzed by using SPSS software. Results Before the treatment,there was no difference in Mo CA and MMSE score between the two group（ P〉0. 05）. MMSE and Mo CA score at 4,8 and 12 week in the observation group were higher than those of the control group,and the difference was statistical significance（ P〈0. 05）. The satisfaction with ADL in the observation group was 88. 89%,which was obviously higher than 66. 67% in the control group,the difference was statistical significance（ P〈0. 05）. The incidence rate of adverse drug reaction in the observation group was 17. 78%,which was similar to 20% in the control group,there had no statistical significance between the two groups（ P〉0. 05）.Conclusion Memantine hydrochloride can effectively improve the cognitive function and daily life quality of patients with parkinsonism dementia. The clinical curative effect is obviously and is worth popularizing in clinic.
出处
《中华全科医学》
2015年第5期722-724,共3页
Chinese Journal of General Practice
关键词
盐酸美金刚
帕金森
认知功能
日常生活
Memantine hydrochloride
Parkinson
Cognitive function
Daily life
