摘要
目的 探讨绝经后器质性或非器质性子宫内膜出血的原因 ,子宫内膜癌及癌前病变的关系。方法 119例患者均进行常规查体及妇科检查 ,宫颈防癌刮片、B型超声波 (腹部或阴道 )测量子宫内膜厚度 ,同时用放免法测定女性激素 ,主要包括血清促卵泡素 (FSH )、促黄体生成素 (LH )、雌二醇(E2 )、孕酮 (P)、泌乳素 (PRL)。行分段性刮宫 ,刮出物做病理组织学检查。统计方法采用 χ2 检验和t检验。结果 子宫内膜病理检查显示 ,增生期子宫内膜 69例 ,腺囊型增生 18例 ,腺瘤型增生 6例 ,萎缩型子宫内膜 16例 ,重度不典型增生 4例 ,子宫内膜癌 2例。分泌期与其他各病理组织学类型比较 ,P <0 .0 1,萎缩型与其他各病理组织学类型比较 ,P <0 .0 1。绝经后腺囊型增生或腺瘤型增生致子宫内膜癌的发生率为 8.3 %。结论 生殖器官炎症和非器质性因素为引起绝经后出血主要原因。发病时年龄越大 ,绝经年限越长 ,出血距初诊时间越长 ,恶性肿瘤的发生率就越大。故绝经后早期开展定期妇科检查 ,积极治疗能引起绝经后出血的常见疾病 。
Object To investigate the reason of postmenopausal organic or the non organic endometrium bleeding, the relationship between carcinoma of endometrium and precarcinomatous pathological changes.Methods All patients received routine physical and gynecological examination,and took cervical scraping.The thickness of endometrium was measured by ultrasonic B,and the abdomen or vagina,as well as the female hormones including the follicle stimulating hormone(FSH),luteining hormone(LH),estrogen(E 2),progestogen(P),prolactin(PRL) were determined by radioimmunssay.Fractional curettage were executed and the thing which had scraped out was sent to be done pathologic histology examination.The statistics method adopted χ 2 test and t test.Results The endometrium pathologic examination showed that the proliferative phase of endometrium 69 cases,cystic hyperplasia of endometrium 18 cases,adenomatous hyperplasia of endometrium 6 cases,atrophic endometrium 16 cases,serious atypical hyperplasia of endometrium 4 cases,carcinoma of endometrium 2 cases.Secreting phase compared with the other pathologic histology types:P<0.01;atrophic type compared with the other pathologic histology types:P<0.01.The occurrence rate of postmenopause cystic hyperplasia or adenomatous hyperplasia causing carcinoma of endometrium was 8.3%.Conclusion The reproductive organ inflammation and the non organic factors were the major reasons causing the postmenopausal bleeding.The age is older,the fixed number of years for menopause is longer,and the bleeding which is apart from the first visit time is longer,the occurrence rate of malignant tumour is higher.Therefore the postmenopausal patients should be taken regularly gynecological examination as early as possible.The common disease causing postmenopausal bleeding should be cured actively and the occurrence of malignant tumour can be reduced.
出处
《河北医药》
CAS
2002年第8期611-613,共3页
Hebei Medical Journal
