摘要
目的探讨脑出血(ICH)患者血清细胞因子的动态变化及其与周围脑组织水肿的相关性。方法选择ICH患者42例设为研究组,正常体检者40例为对照组,检测2组白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、白细胞介素-10(IL-10)、白细胞介素-1β(IL-1β)、转化生长因子-β1(TGF-β1)的水平,并分析其与脑出血量、水肿量的相关性。结果研究组各时间点IL-6、IL-8、IL-10均显著高于对照组(P<0.01),TGF-β1除发病后14 d外,各时间点与对照组差异均有统计学意义(P<0.01);研究组发病后出血量和水肿量均呈动态变化过程,3 d左右达高峰;在发病6 h^3 d时,患者脑水肿量与IL-8、IL-10呈显著正相关(r=0.691,P=0.002;r=0.752,P=0.001)。结论 IL-8、IL-10与ICH的病理过程密切相关,对判断病情严重程度有重要意义。
Objective To explore the dynamic changes of serum cytokines in patients with intracerebral hemorrhage（ ICH） and correlation between changes and peripheral brain edema. Methods A total of 42 ICH patients were designed as research group and 40 healthy people underwent physical examination were designed as control group. Interleukin（ IL）-6,IL-8,IL-10,IL-1β and transforming growth factor（ TGF） β1 levels were detected,and correlations between changes and cerebral hemorrhagic as well as water volumes were analyzed. Results IL-6,IL-8 and IL-10 levels in every time point in the research group were significantly higher than the control group（ P 0. 01）. Except 14 days after treatment,there were significant differences of TGF-β1 level in every time point between the two groups（ P 0. 01）. The volume of cerebral hemorrhage and brain edema extent showed dynamic changes after attack in the research group,and then reached the peak in 3 days. 6 hours to 3day after ICH attacked,the brain edema volume was positively correlated with IL-8 and IL-10（ r = 0.691,P = 0. 002; r = 0. 752,P = 0. 001）. Conclusion IL-8 and IL-10 levels are closely associated with the pathological process of ICH,which is of great significance in the judgment of the severity of disease.
出处
《实用临床医药杂志》
CAS
2015年第5期25-27,共3页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11321387)
