摘要
核因子κB(NF-κB)是一种核转录因子,在调控多种与细胞凋亡、肿瘤发生、炎症和多种自身免疫疾病相关的基因表达中具有重要作用。研究表明,NF-κB信号通路在骨骼肌萎缩的发生和发展中具有关键作用。本文就NF-κB信号通路和骨骼肌萎缩的研究进展进行综述,为更好地研究骨骼肌萎缩的发病机理、探索更加有效安全的治疗方法提供参考。
Nuclear factor κB （NF-κB） is a nuclear transcription factor that regulates expression of a large number of genes that are critical for the regulation of apoptosis, tumorigenesis, inflammation, and various autoimmune diseases. Resent researches have showed that NF-κB signaling plays an important role in the occurrence and development of skeletal muscle atrophy. This article introduces the current advance of NF-κB signaling and skeletal muscle atrophy, in order to make clear pathogenesis of skeletal muscle atrophy and lay the foundation of designing more effective and safer therapies.
出处
《生命的化学》
CAS
CSCD
2015年第2期188-192,共5页
Chemistry of Life
基金
广东省科技计划项目(2011B031600001)
