摘要
目的检测神经元特异性烯醇化酶(NSE)、血清癌胚抗原(CEA)、细胞角蛋白19片段抗原(cytokeratin 19 fragment antigen,CYFRA21-l)、糖类抗原-125(CA125)和糖类抗原-153(CA153)水平,探讨其在肺癌早期诊断和治疗中的临床意义。方法检测87例肺癌患者、50例肺部良性疾病患者和30例健康人血清中NSE、CEA、CA125、CYFRA21-1和CA153的水平。结果肺癌组血清中NSE、CEA、CYFRA21-1、CA125、CA153水平明显高于良性肺部疾病组和健康对照组,差异有统计学意义(P<0.01),而肺良性病变组和健康对照组血清中NSE、CEA、CYFRA21-1、CA125、CA153水平差异无统计学意义(P>0.05);复发组患者血清中NSE、CEA、CYFRA21-1、CA125、CA153水平明显高于未复发组,差异有统计学意义(P<0.01)。5项指标联合检测能明显提高肺癌诊断的敏感性,与单独各项指标敏感性比较差异具有统计学意义(P<0.01)。结论肺癌血清肿瘤标志物在肺癌早期诊断和治疗中具重要的临床价值,并且肿瘤标志物联合检测可以提高肺癌诊断的敏感性。
Objective To detect the carcinoembryonie antigen （CEA）, cytokeratin 19 fragment antigen （ CYFRA21-1）, neuron-specific enolase （ neuron-speeifieenolase, NSE）, carbohydrate antigen -125 （ Carbohydrate antigen-125, CA125 ） and carbohydrate antigen -153 （ Carbohydrate antigen-153, CA153 ） in serum, to investigate the value of serum markers in diagnosis and treatment of lung cancer. Methods The serum levels of the five tumor markers NSE, CEA. CYFRA21-1, CA125 and CA153 were detected in 30 healthy adults,87 patients with lung cancer and 50 patients with respiratory infection by electrochemilumi- nescence. Results The serum NSE, CEA, CYFRA21-1, CA125, CA153 levels were significantly higher in lung cancer than benign lung disease group and healthy control group, the difference was statistically signif- icant （P 〈0. 01 ）, and benign lung disease group and healthy controls group serum NSE, CEA, CYFRA21-1, CA125, CA153 levels showed no significant difference （P 〉0. 05）; serum NSE relapse group, CEA, CY- FRA21-1, CA125, CA153 levels were significantly higher than those without recurrence group, the difference was a statistically significant （P 〈 O. O1 ） ; combined detection of five indicators can significantly improve the diagnostic sensitivity of lung cancer, with significant statistical significance （P 〈 0. 01 ） compared with the sensitivity of the detection alone. Conclusion Detection of the five tumor markers is helpful for lung cancer diagnosis and treatment. Combined tumor markers detection can improve the sensitivity of lung cancer.
出处
《中国肿瘤临床与康复》
2015年第5期519-521,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
肺肿瘤
诊断
标记物
Lung neoplasms
Diagnosis
Tumor marker
