摘要
目的探讨B超引导下对妊娠中期孕妇行羊膜腔穿刺术的临床价值及其安全性和可靠性。方法对湖北省妇幼保健院在2006年01月01日~2011年12月31日4155例接受妊娠中期羊膜腔穿刺术进行产前诊断的孕妇资料进行回顾性分析。结果 4155例行羊膜腔穿刺手术者穿刺全部成功,羊水培养成功率99.69%（4142/4155）,检出染色体异常率4.93%（205/4155）,羊膜腔穿刺术后1周内流产率0.26%（11/4155）,未发现新生儿针刺损伤及孕妇损伤。结论妊娠中期羊膜腔穿刺是安全可靠的侵入性产前诊断方法,以夫妇一方染色体异常为指征的异常染色体发生率显著高于其他如血清学异常、高龄、超声异常、不良孕产史等为指征的染色体发生率。产前超声筛查异常有较高的染色体异常检出率。
Objective：To analyze both the clinical value and the safety and reliablity of amniocentesis. Methods：Retrospective study of the pregnant metaphase through percutaneous ultrasound-monitored amniocentesis on prenatal diagnosis in 4155 cases which were accepted in Maternal and Child Health Hospital of Hubei Province during the January 1st,2006 to December 31 st,2011. Results：All 4155 cases of the amniocentesis were success. Amniotic fluid training success rate was 99.69%（4142/4155）,Check out the chromosome abnormality rate was 4.93%（205/4155）. The abortion rate was 0. 26%（11/4155）in 1 week after percutaneous ultrasound-monitored amniocentesis,and found neither the newborn acupuncture injury nor the pregnant women. Conclusions：Pregnant metaphase of the amniocentesis is a safe and reliable method as a non-invasive prenatal diagnosis. The chromosomal abnormalities of the couple for indications on the incidence of abnormal chromosome is significantly higher than other such as the abnormal serology,older age,abnormal ultrasound and abnormal gestation and birth. Prenatal ultrasound screening abnormal has higher detection rate of the chromosomal abnormalities.
出处
《中国优生与遗传杂志》
2015年第4期57-58,67,共3页
Chinese Journal of Birth Health & Heredity
关键词
羊膜腔穿刺
产前诊断
染色体核型
Prenatal diagnosis
Amniocentesis
Chromosomal karyotype
