摘要
目的通过检测妊娠期糖尿病(GDM)合并子痫前期(PE)患者血清中脂质运载蛋白2(LCN-2)的含量,探讨LCN-2在GDM合并PE中的检测水平及其与相关指标和病情的相关性。方法选取2011年1月至2014年6期间60例GDM合并PE患者为研究对象,60例患者中,30例为轻度PE患者(GDM合并轻度PE组),30例为重度PE患者(GDM合并重度PE组),选择30例单纯GDM患者和30例PE患者为疾病对照组,选择正常妊娠孕妇为正常对照组。检测受试者血尿酸(TG)、游离脂肪酸(FFAs)、尿酸(UA)、24 h尿蛋白、LCN-2水平及胰岛素抵抗指数(HOMA-IR),并对相关指标进行相关性分析。结果 GDM合并PE组FFAs、HOMA-IR、TG、LCN-2、24 h尿蛋白和UA水平最高,差异有统计学意义(P<0.01);正常妊娠组FAs、HOMA-IR、TG、LCN-2、24 h尿蛋白和UA水平最低,差异有统计学意义(P<0.01);GDM合并重度PE组FFAs、HOMA-IR、TG、LCN-2、24 h尿蛋白和UA水平明显高于GDM合并轻度PE组,差异有统计学意义(P<0.01);LCN-2与FFAs、HOMA-IR、TG、24 h尿蛋白和UA均呈正相关(P<0.05),LCN-2与GDM合并PE严重程度呈正相关(P<0.05)。结论 GDM合并PE患者血清LCN-2明显高表达,LCN-2的高表达与GDM合并PE患者的血脂代谢紊乱、胰岛素抵抗密切相关,LCN-2可作为预测GDM合并PE患者疾病严重程度及肾功能损害的指标。
Objective To study expression of lipocalin- 2 in diabetes mellitus complicated with preeclampsia patients and its relationship with the disease. Methods Between January 2011 and June 2014,60 patients with GDM combined with PE were selected as the research object,and of 60 cases of patients,30 cases of patients with mild PE（ GDM with mild PE group）,30 cases of patients with severe PE（ GDM group with severe PE）,30 cases of simple GDM patients and 30 patients with PE were selected as disease control. Normal pregnancy pregnant women were selected as normal control group. Test subjects＇ blood uric acid（ TG）,free fatty acids（ FFAs）,uric acid（ UA）,24 hours urinary protein,LCN- 2（ HOMA IR） level and insulin resistance index,correlation analysis and the related indicators were tested. Results GDM combined with PE group FFAs,HOMA- IR,TG,LCN- 2,24 h urine protein UA levels were the highest. And the difference was statistically significant（ P〈0.01） and normal pregnancy group FFAs,HOMA- IR,TG,LCN 2,24 h urine protein and UA levels were lowest. The difference was statistically significant（ P〈0. 01）. The FFAs,HOMA IR,TG,LCN 2,24 h urine protein and UA levels of GDM group with severe PE were significantly higher than GDM group with mild PE group. The difference was statistically significant（ P〈0. 01）. There were positive correlations between LCN- 2 with FFAs,HOMA- IR,TG,24 h urine protein and UA（ P〈0. 05）,and there were positive correlations between LCN- 2 and GDM group with PE severity（ P〈0. 05）. Conclusion GDM complicated with PE patients＇ serum LCN- 2 was of significantly high expression. The high expression of LCN- 2 closely related with lipid metabolic disorder and insulin resistance in GDM combined with PE,and LCN- 2 can be used as index of the severity of disease and renal impairment of patients with GDM combined with PE.
出处
《临床和实验医学杂志》
2015年第8期664-667,共4页
Journal of Clinical and Experimental Medicine
关键词
妊娠期糖尿病
子痫前期
脂质运载蛋白2
血脂
肾功能
Gestational diabetes mellitus
Preeclampsia
Lipocalin 2
Blood lipid
Renal function
