摘要
目的分析该院2012年临床分离病原菌的细菌分布及耐药情况,为临床合理选用抗菌药物提供参考。方法常规方法进行细菌培养,使用法国梅里埃公司VITEK-32全自动细菌鉴定与药敏系统检测耐药性,使用whonet5.3软件进行数据统计处理。结果 4906份临床标本共分离病原菌1581株,检出率32.23%(1581/4906);革兰阴性菌占71.03%(1123/1581);革兰阳性菌占21.88%(346/1581);真菌占7.08%(112/1581)。鲍曼不动杆菌检出率最高(17.71%,280/1581),其次为铜绿假单胞菌(14.55%,230/1581)和大肠埃希菌(12.27%,194/1581)。金黄色葡萄球菌对苯唑西林耐药率72.50%(58/80),未检出耐万古霉素菌株;屎肠球菌对万古霉素耐药率10.71%(3/28)。结论高度重视细菌耐药情况,结合细菌谱及耐药性合理使用抗生素,减少耐药菌株产生。
Objective To analyse the distribution of pathogenic bacteria and bacterial resistance in our hospital during 2012,and to provide the reference for the clinical rational use of antimicrobial agents. Methods Conventional methods was used for bacterial culture,and VITEK-32 automatic detection system of French Bio Merieux company was used for bacteria identification and bacterial resistance analysis,and whonet 5. 3 software was used for data analysis. Results 1581 strains were isolated from 4906 clinical specimens,and the detection rate was 32. 23%（ 1581 /4906）; Gram negative bacteria accounted for71. 03%（ 1123 /1581）; Gram positive bacteria accounted for 21. 88%（ 346 /1581）; Fungi accounted for 7. 08%（ 112 /1581）.Bauman Acinetobacter detection rate was the highest（ 17. 71%,280 /1581）,followed by Pseudomonas aeruginosa（ 14. 55%,230 /1581） and Escherichia coli（ 12. 27%,194 /1581）. The resistant rate of Staphylococcus aureus to oxacillin was 72. 50%（ 58 /80）,and vancomycin resistant strains were not detected; Resistant rate of Enterococcus faecium to vancomycin was10. 71%（ 3 /28）. Conclusion Conducting monitoring of bacterial drug resistance and grasping the change trend of drug resistance have important significance to guide clinical rational drug use.
出处
《临床合理用药杂志》
2015年第13期3-5,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
致病菌
抗菌药物
耐药率
Pathogenic bacteria
Antibacterial agents
Drug resistance
