摘要
目的探讨桩蛋白(Paxillin)和基质金属蛋白酶-9(MMP-9)在非小细胞肺癌(Non-small cell lung cancer,NSCLC)组织中的表达及临床意义。方法采用免疫组化Enlivision法检测60例NSCLC和38例周围正常肺组织中Paxillin、MMP-9的表达,分析其表达与NSCLC临床病理特征的关系及两者表达的相关性。结果 Paxillin、MMP-9在NSCLC组织中的表达率均明显高于正常肺组织,且其高表达与淋巴结转移密切相关(P<0.05),与性别、年龄、吸烟及病理类型无关(P>0.05);Paxillin与MMP-9在NSCLC组织中的表达呈正相关关系(P<0.05)。结论 Paxillin、MMP-9的表达可能与NSCLC的发生发展、侵袭转移有关,两者有望成为判定NSCLC及预测其侵袭转移能力的指标。
Objective To explore the expressions and significance of paxillin and MMP-9 in the tissue of non-small cell lung cancer. Methods The expressions of paxillin and MMP-9 protein in 60 cases of NSCLC tissues and 38 cases of normal lung tissues around were detected by immunostoemical Enlivision method. The relationship between paxillin and MMP-9 expression and clinical data was also analyzed. Results The positive expression rate of paxillin and MMP-9 in NSCLC was significantly higher than that in normal lung tissues, and the high expression of paxillin and MMP-9 in NSCLC was correlated with lymph node metastasis （ P〈0. 05 ） , having no correlation with sex, age, smoking and pathological type （P〉0. 05）. The expression of paxillin had positive correlation with the ex-pression of MMP-9 （P〈0. 05）. Conclusion The expression of paxillin and MMP-9 may be related with evolution and metastasis of NSCLC. Paxillin and MMP-9 could be a marker to diagnose NSCLC and evaluate invasion and metastasis in NSCLC.
出处
《临床肺科杂志》
2015年第6期985-987,共3页
Journal of Clinical Pulmonary Medicine
