摘要
目的探讨新生儿持续肺动脉高压的高危因素及早期预测方法。方法按照病例对照研究设计,对50例新生儿持续肺动脉高压病例和同期无PPHN的相对健康儿50例对照组进行相关因素的回顾性调查,采用Logistic回归方法进行单因素和多因素分析,在此基础上建立新生儿持续肺动脉高压发病的预测模型,并对模型进行初步评价。结果感染性肺炎(OR=43.665)、新生儿窒息(OR=33.682)、先天性心脏病(OR=30.548)、性别(OR=18.337)、宫内窘迫(OR=17.727)、混合性酸中毒(OR=7.975)、出生体重(OR=1.002)为新生儿持续肺动脉高压发病的主要危险因素。预测回归模型P=1/1+Exp∑(-13.511+2.909X1+3.777X2+3.517X3+2.875X4+3.419X5+2.076X6)的适配度的Chi-square检验结果为86.807,提示P<0.01,模型有显著性意义。结论新生儿持续肺动脉高压是多因素综合的结果,对高危患儿应尽早采取措施,减少患病率及死亡率。
Objective To explore the risk factors and prediction for newborns with persistent pulmonary hypertension （ NPPH） . Methods An case-control study was conducted in 50 newborns of persistent pulmonary hypertension. All factors were used as independent variables for multivariate analysis of Logistic regression, and a predictive model of Logistic regression for the genesis of PPHN was established, and the model was evaluated preliminarily. Results The main risk factors included infectious pneumonia （OR=43. 665）, neonatal asphyxia （OR=33. 682）, congenital heart disease （OR=30. 548）, gender （OR=18. 337）, intrauterine distress （OR=17. 727）, mixed acidosis （ OR=7. 975 ） and birth weight （ OR =1. 002 ） . Goodness of fit for predictive model of Logistic regression checked by Chisquare was 86. 807. It indicated model check{P=1/1＋Exp∑（ -13. 511＋2. 909X1 ＋3. 777X2 ＋3. 517X3 ＋2. 875X4 ＋3. 419X5 ＋2. 076X6）} was statistically significant （P〈0. 01）. Conclusion Persistent pulmonary hypertension of the newborn is the result of multiple factors, and they should be taken measures to reduce morbidity and mortality as soon as possible.
出处
《临床肺科杂志》
2015年第6期1070-1073,共4页
Journal of Clinical Pulmonary Medicine
