摘要
目的:对2011—2013年在深圳市妇幼保健院产科引产或分娩的70例双胎并发胎儿畸形的临床资料进行分析,了解其临床特点。方法:描述孕产妇及胎婴儿的基本临床特征,并分别按受孕方式和绒毛膜性质分为自然受孕组和人工受孕组、单绒毛膜组和双绒毛膜组,比较不同分组的妊娠结局和畸形胎婴儿的主要临床特点。结果:65.71%的孕产妇年龄≥30岁,单绒毛膜双胎占64.29%,人工受孕与自然受孕例数基本相当。妊娠合并症/并发症发生率为91.42%,前5位是早产、宫缩乏力、胎盘异常、选择性生长受限和妊娠期高血压疾病。单一系统畸形占89.33%,前5位是心血管畸形、骨骼肢体畸形、泌尿生殖系统畸形、唇腭裂和神经系统畸形。结论:双胎并发胎儿畸形孕产妇年龄多在30岁以上,并且妊娠合并症/并发症的发生率偏高。双胎畸形中以一胎畸形多见;畸形类型以心血管畸形、骨骼肢体畸形、泌尿生殖系统畸形为多;单一系统畸形比多系统畸形常见。心血管畸形中尤以室间隔缺损多见。因此,对于30岁以上并有妊娠合并症/并发症的双胎妊娠孕妇,必须加强其产前胎儿畸形的筛查,尤其是应专注于检查胎儿的心血管系统、骨骼肢体和泌尿生殖系统。
Objective：To investigate the clinical analysis from 70 cases with malformations in the fetuses of twin pregnancy from 2011 to 2013 at Shenzhen Maternal and Child Heahhcare Hospital. Methods：Describe the clinical characteristics of 70 twin pregnancies complicated with fetal malformations. According to the way of conception and the type of ehorionic ,these twin pregnancies were divided into natural conception and artificial insemination group, monochorionic and dichorionic group respectively, and were compared the pregnancy outcomes and the main clinical characteristics by different groups. Results：65.71% of pregnant women were equal or greater than 30 years old, and 64.29% are monochorionic twins. Pregnancy complications were remarkably higher （91.42%）, the top five complications were preterm labor, weakness of contractions, placental abnormality, selective growth restriction, hypertensive disorders in pregnancy. One fetus affected was 89.33%, the top five abnormalities were cardiovascular system, musculoskeletal system, urogenital system, cleft lip and palate and nervous system. Conclusions：Twin pregnancies complicated with fetal malformations are above 30 years old, and have higher incidence of complications. One fetus affected is more common than both fetuses affected; single defect is more common than multiple defects. A single system malformation is more common than multiple system malformation. The cardiovascular system malformation is the most common malformation in twin fetuses, musculoskeletal system is the second and the urogenital system malformation ranks the third. Especially in ventricular septal defect in cardiovascular malformation. So, for over 30 years old pregnant women with twins and pregnant complications, we must strengthen antenatal fetal malformation screening, and especially should focus on screening cardiovascular system, bone of limbs, urogenital system malformation.
出处
《国际妇产科学杂志》
CAS
2015年第2期229-232,共4页
Journal of International Obstetrics and Gynecology
基金
深圳市科技计划项目(JCYJ20130402094134981)
关键词
双胎疾病
妊娠
先天畸形
Diseases in twins
Pregnancy
Congenital abnormalities
