摘要
目的探讨多重耐药鲍曼不动杆菌检出率变化与多种抗菌药物使用量之间的相关关系。方法采用回顾性分析的方法,调查广州医科大学附属第二医院临床常用六类抗菌药物在2011年7月~2013年12月（每六个月计为半年汇总统计一次）,每半年的平均每日每百张床位所消耗的用药频度（DDDs/100BD）和每半年多重耐药鲍曼不动杆菌检出率的变化,运用SPSS 19.0进行pearson分析同期多重耐药鲍曼不动杆菌检出率与抗菌药物使用量的相关性。结果碳青霉烯类每半年的DDDs/100BD与多重耐药鲍曼不动杆菌检出率之间呈正相关（r=0.93,P〈0.05）,有统计学意义;而青霉素类、头孢菌素类、喹诺酮类、氨基糖苷类和磺胺类每半年的DDDs/100BD与多重耐药鲍曼不动杆菌的检出率无相关关系。结论为延缓耐药菌检出率的快速增加,建议临床治疗中严格掌握抗菌药物应用指征,尽可能根据药敏试验结果选择用药,进一步控制和减少相关抗菌药物的使用量。
Objective To explore the correlation between the detection rate of multi- drug resistant Acinetobacterbaumannii and antimicrobial consumption. Methods Retrospective analysis was used to investigate the antibacterialconsumption in the Second Affiliated Hospital of Guangzhou Medical University from July 2011 to December 2013.Data ofdefined daily doses system of 100 bed per day（DDDs/100BD） as well as the results of multi- drug resistant Acinetobacterbaumannii detection in every six months was collected and their correlation was analyzed with Pearson statistic method bySPSS19.0 software. Results The consumption of carbopenems was positively correlated with detection rate of multi-drugresistant Acinetobacter baumannii（r =0.93, P〈0.05）. There was no significant correlation in other drugs. Conclusion Toprevent rapid increase of multi-drug resistance rate, the antimicrobial consumption should be controlled and antibiotics shouldbe used rationally in accordance with clinical sensitivity test results as far as possible.
出处
《中国热带医学》
CAS
2015年第3期316-318,共3页
China Tropical Medicine
关键词
鲍曼不动杆菌
多重耐药
检出率
抗菌药物用量
Acinetobacter baumannii
Multi-drug resistance
Detection rate
Antimicrobial consumption
