摘要
目的观察罗格列酮对2型糖尿病合并原发性高血压患者的降压效果。方法选择保定市第一中心医院2011年1月至2013年1月收治的126例2型糖尿病合并原发性高血压患者为研究对象,按照随机数字表法分为研究组(72例)和对照组(54例)。对照组给予常规治疗,二甲双胍1500 mg/d及苯那普利15 mg/d。研究组在对照组常规治疗的基础上,给予罗格列酮4 mg/d。观察两组患者治疗1个疗程前后空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A1c)、空腹胰岛素(FINS)、胰岛素敏感指数(ISI)及血压等指标的变化情况,并比较疗效。结果研究组总有效率为93.1%,对照组为72.2%,两组临床疗效比较差异有统计学意义(P<0.05)。治疗后,两组患者的收缩压、舒张压、FPG、2 h PG、Hb A1c水平均低于治疗前(P<0.05),且均低于对照组(P<0.05);研究组治疗前后FINS、ISI比较差异有统计学意义,且优于对照组(P<0.05)。结论罗格列酮可有效降低糖尿病并发原发性高血压患者血糖及血压水平,效果显著,不良反应少,安全可靠。
Objective To observe the antihypertensive effect of rosiglitazone in the treatment for type 2 diabetes mellitus complicated by essential hypertension. Methods A total of 126 patients with type 2 diabe- tes mellitus complicated by essential hypertension admitted in Baoding First Central Hospital from Jan. 2011 to Jan. 2013 were selected as the research objects, and according to random number table, divided into study group（72 cases） and control group（54 cases）. Patients in the control group received conventional treatment of 1500 mg/d mefformin and 15 mg/d benasepril,while patients in the study group received 4 mg/d rosiglita- zone on the basis of treatment in control group. Fasting plasma glucose （ FPG ） , 2-hour plasma glucose （2 h PG）, glyeesylated hemoglobin （HbAlc）, fasting insulin （FINS）, insulin sensitivity index （ISI） as well as the changes in blood pressure and other indicators of efficacy in the two groups were observed before and after a course of treatment. Results The total effective rate of the study group was 93.1%, while that of the control group was 72. 2% , there was statistically significant difference between the two groups （P 〈 0. 05 ）. After treatment,levels of systolic blood pressure, diastolic blood pressure, FPG,2 h PG, HbAtc of both groups were lower than those before therapy （ P 〈 0. 05 ） , and those of the study group was lower than the control group （P 〈 0. 05 ） ;before and after treatment, FINS and ISI of the study group had statistically significant differences, and the differences were superior to those of the control group （ P 〈 0. 05 ）. Conclusion Resigli- tasone can effectively reduce blood pressure and blood sugar levels in patients with diabetes mellitus compli- cated by essential hypertension, with remarkable effect,less adverse reactions, and it is safe and reliable.
出处
《医学综述》
2015年第9期1691-1693,共3页
Medical Recapitulate
关键词
糖尿病
原发性高血压
罗格列酮
降压
Diabetes
Essential hypertension
Rosiglitasone
Antihypertensive
