摘要
目的探讨丹参酮胶囊联合螺内酯对女性青春期后痤疮患者血清性激素水平的影响及临床疗效。方法选择近年来收治的251例女性青春期后痤疮患者,随机分为3组,治疗组采用丹参酮胶囊联合螺内酯治疗,对照组分别采用丹参酮胶囊和螺内酯治疗,比较3组患者的疗效,并观察治疗前后外周血中黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)及睾酮(T)的变化。结果治疗组和对照组总有效率分别为80.23%,65.85%和55.42%,差异有统计学意义(P<0.01);治疗前治疗组和对照组T的水平均明显高于健康对照组(P<0.01)。治疗后治疗组和对照组T的水均明显下降,且治疗组和对照组之间差异有统计学意义(P<0.01),但对照组之间有效率差异无统计学意义(P>0.05)。结论丹参酮胶囊联合螺内酯治疗女性痤疮疗效确切,其可能通过调节机体性激素水平达到治疗寻常痤疮的目的。
Objective To investigate the changes of serum sexhormone levels and the therapeutic effect of tanshinone capsules combined spironolactone on female patients with post-adolescent ache. Methods Two hundred and fifty one female atients with post-adolescent ache were randomly divided into three groups, the treatment group received tanshinone capsules combined with spironolactone therapy, in the control group received tan- shinone capsules or spironolactone treatment alone. The efficacy and the serum levels of luteinizing hormone （ LH）, follicle stimulating hormone （ FSH ）, estradiol （ E2 ） and testosterone （T） in patients with different groups were observed and compared. Results The total effective rate in the treated group and the control group was 80. 23%, 65. 85% and 55.42% respectively, the difference was statistically significant （ P 〈 0.01 ）. The serum level of T in the patients before treatment were higher than that in healthy subjects （P 〈 0. 01 ）. After treatment, it reduced significantly in the treated group （P 〈 0. 01 ）, and showed significant differ- ence between the treated group and the control group （P 〈 0.01 ）, the efficiency were no significant difference between two control groups （P 〉 0.05）. Conclusion Clinical efficacy of tanshinone capsules combined spi- ronolactone on female patients with post-adolescent ache was obvious, and it may play a role through regula- ting the sexhormone level.
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2015年第5期469-471,共3页
The Chinese Journal of Dermatovenereology
关键词
女性青春期后痤疮
丹参酮
螺内酯
性激素
Female post-adolescent acne
Tanshinone
Spironolactone
Sexhormone
