摘要
目的探讨急性坏死性脑病(ANE)的磁共振影像学特征与临床病理的关系。方法资料完整的ANE 2例,结合文献复习其MRI特点,并与临床对照。结果 2例患者均为男性,发病年龄分别为1岁及1岁5个月,有典型的临床表现,发病前有明确的前驱感染史,之后短时间陷入浅昏迷,并有惊厥抽搐发作,脑脊液生化检查蛋白含量增高,MRI示颅内多发、对称性分布病灶,均累及双侧丘脑及脑干并出血,T1WI呈高信号,T2WI呈混杂高信号为主,T2-FLAIR为混杂高信号,增强后呈轻度环形强化,病例1双侧海马受累及,病例2双侧侧脑室旁白质、基底节区、小脑半球受累及。结论急性坏死性脑病MRI最突出的影像学特点是对称性地累及双侧丘脑,而且T1WI常呈高信号。
Objective To evaluate MRI imaging findings of ANE and correlation with clinical pathological studies .Meth‐ods Two cases of ANE with complete clinical data were studied .Their imaging characteristics ,clinical data combined with literature were reviewed .Results Two cases were male ,with typical clinical presentation .The onset of disease was 1 year old and 1 and half year old retrospectively .Both of them had clear history of preceding infection before the onset , lapsed into a coma with convulsive seizure in a short time .The laboratory findings of the CSF revealed the increased level of protein content .MRI showed multiple‐symmetric distribution of lesions ,both involving the bilateral thalamus and brainstem along with hemorrhage ,T1 WI showed hyperintensity ,T2 WI showed mostly hyperintensity ,T2‐FLAIR showed mixed signal intensity .The mild and ring enhancement were observed .The bilateral hippocampus was involved in case 1 . The bilateral white matter of intracerebroventricular ,basal ganglia ,cerebellum were involved in case 2 .Conclusion The most important imaging finding of ANE is the symmetry involvement of the bilateral thalamus ,which often shows hyper‐intensity on T1 WI .
出处
《医学影像学杂志》
2015年第4期580-583,594,共5页
Journal of Medical Imaging
关键词
急性坏死性脑病
磁共振成像
丘脑
鉴别诊断
Acute necrotizing encephalopathy
Magnetic resonance imaging
Thalamus
Differential diagnosis
