摘要
目的 观察卡培他滨联合奥曲肽对乳腺癌MCF-7细胞增殖周期的影响.方法 实验分为4组：对照组、卡培他滨组、奥曲肽组、联合组（卡培他滨＋奥曲肽）.每组分为不同浓度,以MTT法检测细胞增殖状况.结果 卡培他滨与奥曲肽在较高浓度水平联用抑制MCF-7细胞增殖,MCF细胞生长初期（4d内）生长速度较快,滞后逐渐减慢,9d后细胞生长趋于停滞;在高浓度水平联用抑制MCF-7细胞生长,表现为协同作用.结论 卡培他滨联合奥曲肽对MCF-7细胞增殖具有抑制作用.
Objective To study the effect of capecitabine combined with octreotide on proliferation cycle of breast cancer MCF-7 cells.Methods The experiments were divided into 4 groups：control group,capecitabine group,octreotide group,combined group （capecitabine plus octreotide）,and subgroups of each group were set up according to the concentrations.Cell proliferation was measured by methyl thiazol tetrazolium （MTT） assay.Results Combined use of capecitaine and octreotide in high concentrations could inhibited the proliferation of MCF-7 cells.The MCF cells grew faster within 4 days,then gradually slowed down,and 9 days later cell growth tended to stagnate.Capecitaine and octreotide in high concentrations showed a synergistic effect.Conclusion Capecitabine combined with octreotide can inhibit the proliferation of MCF-7 cells.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2015年第5期996-997,共2页
Chinese Journal of Experimental Surgery
关键词
卡培他滨
奥曲肽
乳腺癌
增殖
Capecitabine
Octreotide
Breast cancer
Proliferation
