摘要
Survivin 是凋亡抑制蛋白（IAP）家族中抗凋亡作用最强的成员。Smac 是半胱氨酸蛋白酶的第2个线粒体激活因子，可以通过与 IAP 的结合，来发挥促凋亡作用。二者在卵巢癌组织中的异常表达均与卵巢癌发生发展、治疗耐受及预后密切相关。两者有望在卵巢癌早期诊断及靶向治疗方面发挥重要作用。
Survivin is the strongest member of the inhibitor of apoptosis protein（IAP）family. Smac is the second mitochondria-derived activator of cysteine proteases,which can promote apoptosis by combining with IAP. Abnormal expression of them is closely related with occurrence,development,treatment tolerance and prognosis of ovarian cancer. It is prompted that Survivin and Smac are expected to play important roles in the early diagnosis and targeted therapy of ovarian cancer.
出处
《国际肿瘤学杂志》
CAS
2015年第4期313-315,共3页
Journal of International Oncology
