摘要
目的：观察参苓白术丸治疗肠易激综合征（IBS）的临床效果。方法90例 IBS 患者采用随机数字法分为中成药组和西药组，每组45例。中成药组给予参苓白术丸治疗，西药组给予蒙脱石散治疗。比较两组患者治疗前后的临床症状评分、肠道微生物和血清炎性因子变化，采用问卷调查评价临床症状，用培养法测定粪便中乳酸杆菌、双歧杆菌、肠杆菌和酵母菌，血酶标免疫吸附测定法（ELISA）检测血清 IL-10、IL-18和TNF-α水平。结果两组患者治疗前粪便中厌氧菌减少、需氧菌增多，患者血清 IL-18和 TNF-α含量升高， IL-10含量降低。中成药组干预8周后患者肠道厌氧菌[（B／E 值1．07±0．49）]和血清 IL-10[（43．65±9．52）mg／L]含量上升，需氧菌[（B／E 值1．07±0．49）]、IL-18[（82．06±21．07）mg／L]和 TNF-α[（28．44±10.20）mg／L]含量下降，其中 IL-18下降最明显，与西药组比较差异有统计学意义（t ＝9．926，P ＜0．01）。两组均无不良反应发生。结论参苓白术丸能改善肠道微环境，促进益生菌生长和重塑肠道生物屏障功能，降低促炎性因子水平和提升抑炎因子水平，具有较好的临床效果。
Objective To observe the clinic efficacy of Shenling Baizhu Pill on patients with irritable bowel syndrome（IBS）.Methods Ninety patients with IBS were collected and divided into Chinese patent medicine group and western medicine group by random number method,45 patients in each group,the Chinese patent medicine group received Shenling Baizhu pill group treatment,the western medicine group was gave Smectite Powder treatment.The changes of clinical symptoms,intestinal tract microorganism and serum inflammatory factor of patients were observed and compared between two groups before and after treatment.The clinical symptoms was evaluated by questionnaire, the Lactobacillus,Bifidobacterium,enterobacteria and yeast were determined by cultivation,the levels of IL -10,IL -18 and TNF -αwere detected by enzyme linked immunosorbent assay（ELISA）.Results Two groups before treat-ment of anaerobic bacteria in feces reduction,aerobic bacteria increased serum IL -18 and TNF -alpha content, increased,the content of IL -10 decreased.Shenling Baizhu Pill intervention for 8 weeks in patients with intestinal anaerobic bacteria[（B/E 1.07 ±0.49）]and serum IL -10[（43.65 ±9.52）mg/L]content increased,aerobic bacte-ria[（B/E 1.07 ±0.49）],IL -18[（82.06 ±21.07）mg/L]and TNF -alpha[（28.44 ±10.20）mg/L]decreased. The IL -18 decreased the most,was different with the western medicine group,there was a statistical significance（t =9.926,P 〈0.01）.Two groups had no bad reaction.Conclusion Shenling Baizhu Pill can effectively regulates and improves the intestinal micro -environment,promote the growth of intestinal probiotics and remodeling the intestinal function of biological barrier,decrease the levels of proinflammatory factors and rise the anti -inflammatory factors level,which has a good clinic effect in treating IBS.
出处
《中国基层医药》
CAS
2015年第10期1510-1514,共5页
Chinese Journal of Primary Medicine and Pharmacy
关键词
参苓白术丸
肠易激综合征
肠道微生态
Shenling Baizhu Pill
Irritable bowel syndrome
Intestinal microecology
