摘要
目的探讨老年男性和女性结肠癌患者危险因素以及预后,并进行对比分析。方法该院2007年7月至2010年3月老年结直肠癌患者694例,分为男性组414例和女性组280例。分析2组患者发病情况差异及预后。结果 2组患者均以直肠、乙状结肠、升结肠为主,差异无统计学意义(P>0.05)。男性组以便血(47.10%)、肠梗阻(17.63%)和腹部肿块(34.78%)为主要改变;女性组以腹痛(36.07%)和其他症状(2.86%)为主要改变,2组首发症状比较,除排便习惯外,其他症状差异均有统计学意义(P<0.05)。手术方式和是否化疗差异无统计学意义(P>0.05)。男性组患者的病理类型主要是腺癌(75.12%),女性组主要为黏液癌(59.29%),差异有统计学意义(P<0.05)。2组分化程度差异无统计学意义(P>0.05)。男性组患者溃疡19.57%,隆起24.40%,菜花50.48%,浸润5.56%,女性组分别为7.50%、49.29%、40.36%、2.86%。男性组以溃疡、菜花、浸润型为主,女性组以隆起型多见,差异有统计学意义(P<0.05)。男性组患者以Ⅱ期、Ⅲ期、Ⅳ期多见,女性组Ⅰ期多见,差异有统计学意义(P<0.05)。694例患者全部完成随访,失访率为0。男性组1年生存率为(0.897±0.016),3年生存率为(0.652±0.032),女性组分别为(0.983±0.027)和(0.883±0.049),差异有统计学意义(t=4.230、4.355,P<0.05)。结论对不同性别的老年结直肠癌患者,要注意其不同危险因素,以利于早期诊断和治疗。
Objective To understand the difference of risk factors and prognosis to elderly patients with color ectal cancer in sex Methods 694 elderly patients with colorectal cancer from 2007 July to 2010 March in the hospital admitted in department of oncology patients,were divided into male group（280 cases） and female group （414 cases） the risk factors and prognosis were analize＇d. Results The rectum,sigmoid colon,ascending colon in the elderly male patients were senile to those in female. According to the first symptom of the patients, hematochezla （47.10%） ,in testinal obstruction （17.63 %） and abdominal mass （34.78 %） were the main change in aged men, while women with abdominal pain （36.07 %） and other （2.86%） symptoms as the main change, compared The first symptoms in two groups were significant difference, besides the defecation habits change（P〈0.05）. The two group in the operation mode and whether the two chemotherapy showed no significant difference （P〉 0.05）. Pathological types of senile male patients were mainly adenocarcinoma （75.12 % ）, pathological types of elderly female patients are mainly of mu cinous carcinoma （59.29%） ,There was significant difference, in the pathological type（P〈0.05）. The degree of dif- ferentiation in two groups showed no significant differenee（P〈0.05）. The patients with group of cancer type ulcer is 19.57 %, rise 24.40 %, cauliflower 50.48% in the elderly male;whil infiltration 5.56 % in elderly women group, ul- cer, uplift, cauliflower,infiltration were 7.50 %, 49.29 %, 40.36 %, 2.86 %. Thare were maily in Gross type to male group ulcer, cauliflower,infiltration, while older women with protuberant,thare were significant difference gross type （P〈0.05）. Ⅱ ,Ⅲ, Ⅳ were the mainly stage in elderly male patients, while the stage I were seen more in older women. 1 year survival rate was （0. 897 ±0. 016）, the 3 year survival rate was （0. 652± 0. 032） in the old male group; but 1 year survival rate and 3 year survival rates were （0. 983±0. 027） and （0. 883±0. 049） in aged female group. Two groups of 1 year survival rate and 3 year survival rate were significant difference （t=4. 230 and 4. 355 ,P 〈0.05）. Conclusion There are some differences in risk factors in elderly male and female patients, pecial attention should be paid to the different risk factors to facilitate the early diagnosis and treatment.
出处
《检验医学与临床》
CAS
2015年第11期1562-1564,共3页
Laboratory Medicine and Clinic
关键词
结直肠癌
性别
预后危险因素
colorectal cancer
gender
prognostic factors
